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Stevens-Johnson syndrome with overlapping features of DRESS syndrome: A report of two cases.
SAGE Open Med Case Rep
December 2024
Division of Dermatology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
Stevens-Johnson syndrome and drug reaction with eosinophilia and systemic symptoms are severe cutaneous adverse reactions to drugs that are generally considered distinct entities. In addition to identifying the offending medication, distinguishing between these diagnoses is important, as they have differing treatment regimens and prognoses. Distinction between severe cutaneous adverse reactions, particularly in the early stages of disease, can be difficult, and overlapping conditions have been reported in the literature.
View Article and Find Full Text PDFA Singular Case Analysis: Lamotrigine-Associated Stevens-Johnson Syndrome.
Case Rep Crit Care
November 2024
Department of Clinical Pharmacy, Nepal Cancer Hospital and Research Center, Harisiddhi, Lalitpur, Nepal.
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is an immune complex-mediated hypersensitivity reaction linked as an adverse side effect to many drugs. There have been case reports of similar incidences in Nepal related to various medications. Here, we present a case of a 29-year-old lady who developed a generalized erythematous rash over her body and erosion of the oral mucous membrane.
View Article and Find Full Text PDFAcquired Type 1 Brugada Syndrome Induced by Chronic High-Dose Kratom Use.
Cureus
October 2024
Department of Emergency Medicine, Memorial Healthcare System, Hollywood, USA.
Article Synopsis
- Kratom, a natural substance used for chronic pain and opioid withdrawal, has been linked to serious heart conditions, particularly Brugada syndrome.
- A 36-year-old male with a history of substance abuse and underlying health conditions experienced chest pain, lightheadedness, and palpitations after using high doses of kratom for three years.
- His case revealed a type 1 Brugada pattern on an EKG, leading to the diagnosis of Brugada syndrome as a result of chronic kratom use, emphasizing the need for medical professionals to be aware of the potential severe cardiac risks associated with kratom.
COVID-19 and severe cutaneous allergic reactions to sulfonamides.
Allergy Asthma Proc
November 2024
From the Section of Allergy, Asthma and Immunology, Department of Medicine, Pennsylvania State College of Medicine, Hershey, Pennsylvania and.
Sulfonamides are associated with severe cutaneous adverse reactions (SCARs). Coronavirus disease 2019 (COVID-19) triggers an immune response, which may increase the likelihood of developing a hypersensitivity reaction. We sought to explore the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the probability of developing SCARs and/or erythema multiforme (EM) reactions to sulfonamides.
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