Calcium channel blockers are used more and more in pregnancy. No teratogenic effect has been observed in humans despite the lack of adequate studies. The use of calcium channel blockers in premature labor and in arterial hypertension may be recommended. In premature labor, maternal tolerance is better than that of beta adrenergic drugs. In hypertensive disorders of pregnancy, current data indicate that calcium channel blockers may be a good second line medication. Acute lowering of maternal blood pressure (by sublingual or intravenous use) may however induce fetal distress.
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