MDMA or 3,4-methylenedioxymethamphetamine, more commonly called "ecstasy", is a drug classified as a stupefiant and increasingly used by young people for its stimulant and hallucinogen effects. This popular designer drug is often used in techno or rave parties and perceived by users as relatively harmless. It has however been associated with disorders of thermoregulation and has been the cause of several deaths. In addition, the drug has been shown to destroy serotonin receptors in the brain in the monkey and leads to serious physchiatric disorders and liver damage in man.
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Sci Rep
March 2024
Department of Forensic Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, 8200, Aarhus N, Denmark.
The neurotransmitter serotonin plays a pivotal role in mood and depression. It also acts as a vasoconstrictor within blood vessels and is the main neurotransmitter in the gastrointestinal system. In neurotransmission, released serotonin is taken up by serotonin transporters, which are principal targets of antidepressants and the psychostimulant, ecstasy.
View Article and Find Full Text PDFSex Med Rev
June 2024
Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center Shreveport, Shreveport, LA, 71103, United States.
Introduction: Recreational psychostimulants have been associated with increased sexual activity or changes in sexual function in women, but every drug in this class has not shown consistent sexual effects in scientific studies. Further, some studies in female animal models may recapitulate the effects observed in humans, while others produce conflicting results. Overall, though, published studies on the sexual effects of recreational stimulants in women are lacking.
View Article and Find Full Text PDFAdv Pharmacol
March 2024
Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA, United States. Electronic address:
Synthetic cathinone derivatives comprise a family of psychoactive compounds structurally related to amphetamine. Over the last decade, clandestine chemists have synthesized a consistent stream of innovative cathinone derivatives to outpace governmental regulatory restrictions. Many of these unregulated substances are produced and distributed as designer drugs.
View Article and Find Full Text PDFJ Ethn Subst Abuse
March 2024
Universidade Franciscana - UFN, Santa Maria, Rio Grande do Sul, Brazil.
University students frequently resort to psychostimulants to enhance their physical and mental performance and manage academic pressures. However, these substances can lead to dependence and other undesired symptoms, and little empirical data are available for relevant stakeholders, raising significant concerns in health care. Therefore, this study aims to characterize neurostimulant use among university students in Rio Grande do Sul, Brazil.
View Article and Find Full Text PDFEnviron Pollut
March 2024
Institute for Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18, 08034 Barcelona, Spain. Electronic address:
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