Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/nsb1296-995 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of NQO1 Downregulation on the Migration and Invasion of HPV16-Positive Cervical Cancer Cells.
Asian Pac J Cancer Prev
December 2024
Center of Excellence in Applied Medical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Objective: This study aimed to identify upregulated genes in HPV16-positive cervical cancer cells and investigate the impact of downregulating NAD(P) H:quinone oxidoreductase 1 (NQO1) on the survival of these cells.
Methods: Transcriptomic sequencing (RNA-seq) was utilized to pinpoint upregulated genes and associated cancer-related pathways in HPV16-positive cervical cancer cells, comparing them to HPV-negative cervical cancer cells. NQO1 gene knockdown was performed in HPV16-positive cervical cancer cell lines to assess its effect on cell survival, including parameters such as cell proliferation, migration, invasion, cell cycle progression, apoptosis, and the expression of key proteins in the PI3K/AKT pathway, p53, and RECK.
Exogenous methyl jasmonate (MeJA) mediated carbohydrate metabolism in apple fruit during ripening.
Plant Physiol Biochem
January 2025
College of Food Science and Technology, Bohai University, Jinzhou, 121013, PR China; National and Local Joint Engineering Research Center of Storage, Processing and Safety Control Technology for Fresh Agricultural and Aquatic Products, Jinzhou, 121013, PR China.
Carbohydrate metabolism plays an essential role in mediating quality and ripening of postharvest fruit. Previous work has demonstrated the regulatory role of methyl jasmonate (MeJA) in ripening of apple fruit. However, the role of MeJA in mediating carbohydrate metabolism of ripening apple fruit is unexplored.
View Article and Find Full Text PDFMitochondrial Nicotinamide Nucleotide Transhydrogenase: Role in Energy Metabolism, Redox Homeostasis, and Cancer.
Antioxid Redox Signal
November 2024
Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands.
Article Synopsis
- Dimeric nicotinamide nucleotide transhydrogenase (NNT) is a crucial enzyme located in the mitochondrial inner membrane, involved in converting NADP/NADH to NADPH/NAD while facilitating proton influx, but its specific roles and regulation in health and diseases like cancer are still not thoroughly understood.! -
- Research on NNT has been conducted through studies on gene mutations in specific models (like GCCD4 patients and C57BL/6J mice) and effects of NNT alterations in cancer cells, revealing both common and unique functional issues, yet information on NNT's physiological role in humans remains limited.! -
- To advance understanding of NNT's functions and effects in various conditions, future
Article Synopsis
- The study analyzed the enzymatic activity of several dehydrogenases in lymphocytes from 183 women with pelvic varicose veins (PVV) and a control group of 30 women.
- Results showed that women with stage II PVV had increased activity in certain enzymes like NAD-GDH and lactate dehydrogenase, while showing decreased activity in NAD-ICDH.
- In stage III PVV, lower levels of succinate dehydrogenase and NAD-MDH were observed, alongside increased levels of other enzymes, highlighting changes in enzyme activity as the disease progresses and suggesting potential for targeted treatment options.
Nuclear localization of MTHFD2 is required for correct mitosis progression.
Nat Commun
November 2024
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain.
Subcellular compartmentalization of metabolic enzymes establishes a unique metabolic environment that elicits specific cellular functions. Indeed, the nuclear translocation of certain metabolic enzymes is required for epigenetic regulation and gene expression control. Here, we show that the nuclear localization of the mitochondrial enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) ensures mitosis progression.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!