AI Article Synopsis
- Research shows that sex differences in home range size and spatial ability in rodents are linked to differences in hippocampus size, influenced by prenatal hormone exposure.
- In Mongolian gerbils, it was predicted that males would have larger hippocampi than females due to their larger home ranges in the wild.
- The study confirmed that randomly selected male gerbils had larger hippocampi than females, but no significant size difference was found in males and females from specific intrauterine positions (2F and 2M).
Article Abstract
Sex differences in home range size and spatial ability are predictive of sex differences in the relative size of the hippocampus in rodents. Such differences in behavior and hippocampal volume are presumed to be, in part, the result of differences in perinatal exposure to hormones. We predicted from differences in the size of home ranges of male and female Mongolian gerbils (Meriones unguiculatus) in the wild that the hippocampus of male gerbils would be relatively larger than that of females. We examined the effect of prenatal hormonal influences on hippocampal size by comparing hippocampal volume of males and females from 2F and 2M intrauterine positions to that of randomly selected males and females. We found that, as predicted, randomly selected males had a significantly larger hippocampus, relative to telencephalon, than did randomly selected females. However, males and females from 2F and 2M intrauterine positions did not differ in relative hippocampal size. Possible explanations for the absence of a sex difference in hippocampal size in male and female gerbils from 2F and 2M intrauterine positions are discussed.
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| http://dx.doi.org/10.1016/s0031-9384(96)00311-3 | DOI Listing |
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