AI Article Synopsis
- The report analyzes genetic changes in 209 workers exposed to vinyl chloride monomer at Dow Chemical over up to 28 years.
- It compares their cytogenetic findings with those of individuals seeking employment, finding no significant differences in chromatid or chromosome aberrations.
- The study suggests that genetic damage is likely linked to exposure duration and that risks can be minimized in environments with controlled and limited exposure.
Article Abstract
This report presents cytogenetic findings from a group of 209 workers employed for up to 28 years in the manufacture of vinyl chloride monomer at the Texas Division of Dow Chemical U.S.A. Cytogenetic evaluation results from this group were compared to results found in examination of individuals being considered for employment. Statistical analyses were performed on a group basis for chromatid aberrations, chromosome aberrations and proportion of abnormal cells; no statistical difference of significance was found between the two groups. Comparison of these results with reported studies suggests that the level of cytogenetic aberrations in vinyl chloride workers is probably related to the length and level of exposure, and that risk of adverse genetic effect can be avoided in controlled, minimal-exposure environments.
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