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Probing the orientation and membrane permeation of rhodamine voltage reporters through molecular simulations and free energy calculations.
J Mater Chem B
January 2025
Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Article Synopsis
- The transmembrane potential is crucial for cellular functions like signaling and energy production, with Rhodamine voltage reporters (RhoVRs) serving as small, non-invasive sensors that can detect voltage changes, especially in mitochondria.
- Extensive simulations and free-energy calculations revealed that the orientation of RhoVRs relative to membranes, influenced by their polarized functional groups, significantly impacts their voltage sensitivity and localization within cells.
- The study's findings on the relationship between the chemical structure of RhoVRs and their membrane behavior offer valuable insights for designing fluorescent dyes that better detect voltage changes.
DOPAC as a modulator of α-Synuclein and E46K interactions with membrane: Insights into binding dynamics.
Int J Biol Macromol
January 2025
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy. Electronic address:
α-Synuclein (Syn) is an intrinsically disordered protein, abundant in presynaptic neurons. It is a constituent of the Lewis Body inclusions as amyloid fibrils, in Parkinson's disease patients. It populates an ensemble of conformations and floats between the free random coil and the membrane-bound α-helical species.
View Article and Find Full Text PDFDifferential regulatory effects of the N-terminal region in SYK-fusion kinases reveal unique activation-inducible nuclear translocation of ITK-SYK.
Sci Rep
January 2025
Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred Nobels Allé 8, Floor 8, 14152, Huddinge, Sweden.
ITK-SYK and TEL-SYK (also known as ETV6-SYK) are human tumor-causing chimeric proteins containing the kinase region of SYK, and the membrane-targeting, N-terminal, PH-TH domain-doublet of ITK or the dimerizing SAM-PNT domain of TEL, respectively. ITK-SYK causes peripheral T cell lymphoma, while TEL-SYK was reported in myelodysplastic syndrome. BTK is a kinase highly related to ITK and to further delineate the role of the N-terminus, we generated the corresponding fusion-kinase BTK-SYK.
View Article and Find Full Text PDFDynamic properties of isotropic DMPC/DHPC bicelles: Insights from solution NMR and MD simulations.
Biochem Biophys Res Commun
January 2025
Graduate School of Chemical Sciences and Engineering, Hokkaido University, N13, W8, Sapporo, 060-8628, Japan; Department of Chemistry, Faculty of Science, Hokkaido University, N8, W5, Sapporo, 060-0810, Japan. Electronic address:
Bicelles, an artificial disk-shaped lipid bilayer, are commonly used for the structural and functional characterization of membrane-bound proteins in an environment similar to that in intracellular membranes. Because the dynamics of the lipids that constitute bicelles exert a significant impact on the structure and function of the inserted proteins, we investigated the mobility of lipid molecules in bicelles composed of DMPC (14:0 PC) and DHPC (06:0 PC) using solution NMR and MD calculations. C R relaxation experiments for the acyl groups demonstrated that increasing bicelle sizes limit the rotational diffusion of acyl chain H-C bonds in DMPC.
View Article and Find Full Text PDFCirculating small extracellular vesicles as blood-based biomarkers of muscle health in aging nonhuman primates.
Geroscience
December 2024
Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Article Synopsis
- Aging leads to loss of muscle mass and function, resulting in poorer health outcomes, decreased quality of life, and increased mortality risk among older adults.
- Small extracellular vesicles (sEV), which can be isolated from body fluids and contain specific biomarkers, offer a minimally invasive way to assess muscle health.
- Research on vervet monkeys showed that sEV from different age groups can reveal molecular changes related to muscle metabolism and regulation, suggesting they may serve as effective biomarkers for muscle health monitoring.
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