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Modulating Cognitive Function with Antihypertensive Medications: a Comprehensive Systematic Review On FMRI Studies.
Clin Neuroradiol
January 2025
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Hypertension (HTN) is a prevalent cardiovascular condition associated with cognitive impairments, including memory deficits and attention lapses. Understanding the neural mechanisms underlying HTN-related cognitive dysfunction is crucial for optimizing treatment strategies.
Method: A systematic review was conducted to explore the impact of antihypertensive medications on cognition, focusing on memory, attention, and emotion processing using functional magnetic resonance imaging (fMRI).
Plasticity of human resilience mechanisms.
Sci Adv
January 2025
Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France.
The hippocampus's vulnerability to trauma-induced stress can lead to pathophysiological disturbances that precipitate the development of posttraumatic stress disorder (PTSD). The mechanisms of resilience that foster remission and mitigate the adverse effects of stress remain unknown. We analyzed the evolution of hippocampal morphology between 2016/2017 and 2018/2019, as well as the memory control mechanisms crucial for trauma resilience.
View Article and Find Full Text PDFTrauma and the default mode network: review and exploratory study.
Front Behav Neurosci
December 2024
Center for Neuropsychology and Consciousness, Miami, FL, United States.
While PTSD continues to be researched in great depth, less attention has been given to the continuum of traumatic responses that resides outside this diagnosis. This investigation begins with a literature review examining the spectrum of responses through the lens of the default mode network (DMN). To build upon this literature, a systematic exploratory study was incorporated, examining DMN-related neuropsychological functioning of 27 participants (16 trauma-exposed, and 11 non-trauma-exposed), with a subset (15 participants) completing neuroimaging.
View Article and Find Full Text PDFDeep brain stimulation of the medial forebrain bundle promotes the extinction of active avoidance and is associated with mossy fibber sprouting in the hippocampus.
Behav Brain Res
March 2025
Departament de Biologia, Universitat de Girona, Girona, Spain. Electronic address:
Background: Post-traumatic stress disorder (PTSD) causes intrusive symptoms and avoidance behaviours due to dysregulation in various brain regions, including the hippocampus. Deep brain stimulation (DBS) shows promise for refractory PTSD cases. In rodents, DBS improves fear extinction and reduces anxiety-like behaviours, but its effects on active-avoidance extinction remain unexplored.
View Article and Find Full Text PDFSex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism.
Commun Biol
December 2024
Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804, Munich, Germany.
Early life stress (ELS) can negatively impact health, increasing the risk of stress-related disorders, such as post-traumatic stress disorder (PTSD). Importantly, PTSD disproportionately affects women, emphasizing the critical need to explore how sex differences influence the genetic and metabolic neurobiological pathways underlying trauma-related behaviors. This study uses the limited bedding and nesting (LBN) paradigm to model ELS and investigate its sex-specific effects on fear memory formation.
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