Objective: To emphasize the continued incidence of phenformin-associated lactic acidosis.
Case Report: We report a case of phenformin-associated lactic acidosis in a Chinese man who received phenformin while in China. Diagnosis was made; the patient was treated appropriately and survived.
Comments: Phenformin-associated lactic acidosis may still occur in the U.S.
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Metformin-associated lactic acidosis: a rare or very rare clinical entity?
Diabet Med
April 1999
Diabetes Unit, Medicine Directorate, Imperial College School of Medicine, Chelsea & Westminster Hospital, London. NN KA
Aims: Lactic acidosis is a well recognized complication of biguanide therapy which is potentially serious. Although the prevalence of metformin-associated lactic acidosis (MALA) is much lower than that associated with phenformin, it is still being reported sporadically which raises concerns for the practising clinicians. We review the currently available world-wide data of the prevalence of MALA, the risk factors for its development and the current practical guidelines on the use of metformin to minimize the risk of this potential hazard.
View Article and Find Full Text PDFPhenformin-associated lactic acidosis due to imported phenformin.
Diabetes Care
December 1996
Department of Medicine, New York Hospital Medical Center of Queens, Flushing 11355, USA.
Objective: To emphasize the continued incidence of phenformin-associated lactic acidosis.
Case Report: We report a case of phenformin-associated lactic acidosis in a Chinese man who received phenformin while in China. Diagnosis was made; the patient was treated appropriately and survived.
[Lactic acidosis shock. Report of a clinical case].
Minerva Cardioangiol
November 1996
Unità Ospedaliera Malattie Cardiovascolari, Ospedale di Volterra, Pisa.
Lactic acidosis is a severe metabolic disorder with multiple pathogenesis; biguanides increase serum lactate. The authors describe a case of phenformin-associated acidosis enhanced by predisposing conditions (dilated cardiomyopathy, renal failure, hypothyroidism). Causative mechanisms and consequences on production/clearance lactic acid cycle are discussed.
View Article and Find Full Text PDFPossible role of intracellular Ca2+ in the toxicity of phenformin.
Biochem Pharmacol
January 1988
Department of Biochemistry, University of Surrey, Guildford, U.K.
Selective use of various mitochondrial Ca2+ transport inhibitors indicated that significant Ca2+ redistribution may occur during the isolation of mitochondria. Exposure of guinea-pig liver mitochondria to phenformin (beta-phenethylbiguanide) during the isolation procedure resulted in decreased mitochondrial Ca2+. Novel isolation conditions were developed to determine liver mitochondrial calcium content considered to reflect that in vivo.
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