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In-Situ Construction of LiCl-Rich Artificial Solid Electrolyte Interphase for High-Performance Lithium Metal Anode.
ChemSusChem
January 2025
Harbin University of Science and Technology, School of Electrical and Electronic Engineering, CHINA.
In the pursuit of high-energy-density lithium metal batteries (LMBs), the development of stable solid electrolyte interphase (SEI) is critical to address issues such as lithium dendrite growth and low Coulombic efficiency. Herein, we propose a facile strategy for the in-situ fabrication of a LiCl-rich artificial SEI layer on Li surfaces through reaction of MoCl5 with Li (Li@MoCl5). The resulting artificial SEI significantly enhances the uniformity of Li deposition, effectively suppresses dendrite formation, and improves electrochemical performance.
View Article and Find Full Text PDF[The clinical significance of resolvin D1 in patients with systemic lupus erythematosus treated with Belimumab].
Zhonghua Yi Xue Za Zhi
February 2025
Department of Rheumatology, the First Affiliated Hospital of Soochow University, Suzhou 215000, China.
To explore the changes and significance of resolvin D1 (RvD1) in the treatment of systemic lupus erythematosus (SLE) with Belimumab. The clinical data from patients with moderate to severe disease activity SLE who received oral stable doses of glucocorticoids (≤10 mg/d) and/or immunosuppressants for more than 3 months at the outpatient or inpatient department of the First Affiliated Hospital of Soochow University from January 2022 to November, 2023 were retrospectively collected. All patients were treated with 10 mg/kg intravenous infusion of Belimumab.
View Article and Find Full Text PDFDeveloping a highly efficient 4-hydroxyphenylacetate-3-hydroxylase for salvianic acid A synthesis by computer-aided molecular modification.
Int J Biol Macromol
January 2025
Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; School of Biological and Chemical Engineering, NingboTech University, Ningbo 315100, China; Jinhua Advanced Research Institute, Jinhua 321019, China. Electronic address:
Salvianic acid A (SAA) is a catechol compound known for its diverse physiochemical functions and has significant applications in the food and pharmaceutical industries. 4-Hydroxyphenylacetate-3-hydroxylase (4HPA3H) is a critical enzyme for SAA biosynthesis, and improving its activity towards p-hydroxyphenyllactate acid (4HPLA) is essential for highly efficient SAA production in stable biosynthetic pathways. To address this, the distal site and loops of the substrate pocket were modified to improve 4HPA3H catalytic activity towards 4HPLA using computer-aided molecular modification methods.
View Article and Find Full Text PDFLysyl oxidase nanozyme-loaded hydrogel for sustained release and promotion of diabetic bone defect regeneration.
J Control Release
January 2025
College of pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China. Electronic address:
The process of regenerating bone injuries in diabetic presents significant challenges because lysine oxidase (LOX), a key catalytic enzyme for collagen cross-linking, is inhibited in hyperglycemia. The supplementation of LOX is constrained by inadequate sources and diminished enzymatic activity, necessitating the development of effective alternatives for enhancing bone regeneration in diabetes. Herein, we reported a lysyl oxidase nanozyme (LON), derived from the catalytic domain of LOX.
View Article and Find Full Text PDFNano- and meso-scale aggregation of poly(N-isopropylacrylamide) below the lower critical solution temperature: A wide-angle dynamic light scattering study.
J Colloid Interface Sci
January 2025
Nanoscale Biophotonics Laboratory, University of Galway, University Road, Galway H91 TK33 Ireland. Electronic address:
Poly-N-isopropylacrylamide (PNIPAm), a thermorresponsive polymer, highly soluble in water below its lower critical solution temperature (LCST), is widely used in biomedical applications like drug delivery. Being able to measure PNIPAm size and aggregation state in solution quickly, inexpensively, and accurately below the LCST is critical when stoichiometric particle or molecular ratios are required. Dynamic light scattering (DLS) is probably the most widely available, and inexpensive nanoparticle sizing technique, but there are limitations with respect to sample polydispersity.
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