A system for monitoring multiple scatter during a clinical Compton scatter densitometry measurement of bone density is described. Multiple scatter from the measurement site was measured using a supplementary collimated detector positioned so that only multiply scattered photons could enter the detector. The data from the detector were used to form a multiple-scatter correction factor (mcf) to correct for the bias attributed to multiple scatter. The results of experimental and computer simulations are presented which demonstrate the relationship between the multiple-scatter reading and calculated mcf values. The influence of bone size on the values of mcf in large measurement sites, such as the femoral neck, was shown to be negligible. A simulation was used to produce a visualization of the multiple scatter in order to ascertain the optimum position of the supplementary detector. This technique was shown to be a rapid and accurate method of measuring the multiple-scatter bias and suitable for use during clinical CSD measurements.
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Plant Dis
January 2025
Tamil Nadu Agricultural University, Department of Plant Pathology, Coimbatore, Tamil Nadu, India;
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View Article and Find Full Text PDFClin Nucl Med
January 2025
From the Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland.
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View Article and Find Full Text PDFMAbs
December 2025
Ichnos Glenmark Innovation, New York, NY, USA.
ISB 1442 is a bispecific biparatopic antibody in clinical development to treat hematological malignancies. It consists of two adjacent anti-CD38 arms targeting non-overlapping epitopes that preferentially drive binding to tumor cells and a low-affinity anti-CD47 arm to enable avidity-induced blocking of proximal CD47 receptors. We previously reported the pharmacology of ISB 1442, designed to reestablish synthetic immunity in CD38+ hematological malignancies.
View Article and Find Full Text PDFAnal Chem
January 2025
Chemistry Department, Indiana University, Bloomington, Indiana 47405, United States.
Charge detection mass spectrometry (CD-MS) is an emerging single-particle technique where both the / and charge are measured individually to determine each ion's mass. It is particularly well-suited for analyzing high mass and heterogeneous samples. With conventional MS, the loss of charge state resolution with high mass samples has hindered the direct coupling of MS to separation techniques like size exclusion chromatography (SEC) and forced the use of lower resolution detectors.
View Article and Find Full Text PDFA key contribution to X-ray dark-field (XDF) contrast is the diffusion of X-rays by sample structures smaller than the imaging system's spatial resolution; this is related to position-dependent small-angle X-ray scattering. However, some experimental XDF techniques have reported that XDF contrast is also generated by resolvable sample edges. Speckle-based X-ray imaging (SBXI) extracts the XDF by analyzing sample-imposed changes to a reference speckle pattern's visibility.
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