Chronic alcohol exposure appears to suppress cell-mediated immunity which may contribute to the high incidence of infections among alcohol-dependent patients. We measured serum neopterin, as a marker of macrophage function and T-lymphocyte activation, in 26 alcohol-dependent patients. The mean serum neopterin in these patients was significantly lower than the mean serum neopterin in matched controls. In those who abstained, the mean serum neopterin at 3 weeks rose and was no longer significantly different from controls. Our findings suggest that alcohol-dependent patients have suppressed macrophage function which may be reversible within 3 weeks of abstention.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/000456329603300608 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The influence of ethanol consumption on a course of endometriosis.
Ginekol Pol
January 2025
I Chair and Department of Gynecology, Medical University of Lublin, Poland.
Objectives: Due to the increasingly faster pace of life and responsibilities, stress has become an integral part of daily life. Every year, numerous social campaigns in the media raise the issue of increasing alcohol consumption. Endometriosis is a chronic, causally incurable, estrogen-dependent and inflammatory gynecological disorder, described as presence of ectopic endometrial tissue outside the uterine cavity.
View Article and Find Full Text PDFScreening for Alcohol Use Disorder Among Hospitalised Patients: Learning from a Retrospective Cohort Study in Secondary Care.
J Clin Med
December 2024
Nottingham Digestive Diseases Biomedical Research Centre (NDDC), School of Medicine, University of Nottingham, Nottingham NG7 2GT, UK.
Excessive alcohol consumption is among the leading causes of hospitalisation in high-income countries and contributes to over 200 medical conditions. We aimed to determine the prevalence and characteristics of alcohol use disorder (AUD), describe the distribution of AUD in ICD-10 discharge diagnosis groups and ascertain any relationship between them in secondary care. The study group was a retrospective cohort of adult patients admitted to Nottingham University Hospital (NUH) between 4 April 2009 and 31 March 2020.
View Article and Find Full Text PDFAssociation of altered cortical gyrification and working memory in male early abstinent alcohol-dependent individuals.
Brain Res Bull
January 2025
Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Department of Neurobiology, Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou 310063, China; Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, 1369 West Wenyi Road, Hangzhou 311121, China. Electronic address:
Background: Alcohol dependence (AD) is an addictive disorder with multifaceted neurobiological features. Recent research on the pathophysiological mechanisms of AD has emphasized the important role of dysconnectivity. Cortical gyrification is known to be a reliable marker of neural connectivity.
View Article and Find Full Text PDFPrefrontal electrophysiological biomarkers and mechanism-based drug effects in a rat model of alcohol addiction.
Transl Psychiatry
December 2024
Department of Psychiatry and Psychotherapy, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Patients with alcohol use disorder (AUD) who seek treatment show highly variable outcomes. A precision medicine approach with biomarkers responsive to new treatments is warranted to overcome this limitation. Promising biomarkers relate to prefrontal control mechanisms that are severely disturbed in AUD.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!