Separation of alkyl derivatives of uracil by solvophobic adsorption chromatography on spheron.

Derivatives of such related substances as cytosine, uracil, thymine, 6-methyl-uracil, 5-ethyluracil, 5-propyluracil, 5-isopropyluracil, 5-cyclopropyluracil, 5-allyluracil, 5,6-trimethyleneuracil, 6-cyclopropyluracil, 5-cyclobutyluracil and 5-tert-butyluracil have been separated on a column of Spheron P-300. Retention on the column was found to depend on the size of the non-polar part of the molecule. The chromatographic behaviour is analyzed according to the theory of solvophobic chromatography.