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Graph contrastive learning of subcellular-resolution spatial transcriptomics improves cell type annotation and reveals critical molecular pathways.
Brief Bioinform
November 2024
School of Artificial Intelligence, Jilin University, Qianjin Street 2699, 130010 Changchun, China.
Imaging-based spatial transcriptomics (iST), such as MERFISH, CosMx SMI, and Xenium, quantify gene expression level across cells in space, but more importantly, they directly reveal the subcellular distribution of RNA transcripts at the single-molecule resolution. The subcellular localization of RNA molecules plays a crucial role in the compartmentalization-dependent regulation of genes within individual cells. Understanding the intracellular spatial distribution of RNA for a particular cell type thus not only improves the characterization of cell identity but also is of paramount importance in elucidating unique subcellular regulatory mechanisms specific to the cell type.
View Article and Find Full Text PDFMapping Key Populations to Develop Improved HIV and AIDS Interventions: Multiphase Cross-Sectional Observational Mapping Study Using a District and City Approach.
JMIR Public Health Surveill
January 2025
Monitoring, Evaluation, and Learning Platform USAID, Jakarta, Indonesia.
Background: Indonesia's vast archipelago and substantial population size present unique challenges in addressing its multifaceted HIV epidemic, with 90% of its 514 districts and cities reporting cases. Identifying key populations (KPs) is essential for effectively targeting interventions and allocating resources to address the changing dynamics of the epidemic.
Objective: We examine the 2022 mapping of Indonesia's KPs to develop improved HIV and AIDS interventions.
Development and validation of an MMPI-3 Antagonism scale.
Personal Disord
January 2025
Department of Psychological Science, Kent State University.
Antagonism is a personality domain located in most major trait models and is central to multiple personality disorders. This construct has been linked to many societally harmful externalizing behaviors (e.g.
View Article and Find Full Text PDFA glass half full of money: Dispositional optimism and wealth accumulation across the income spectrum.
J Pers Soc Psychol
January 2025
Marketing Division, Paul College of Business and Economics, University of New Hampshire.
What drives some people to save more effectively for their future than others? This multistudy investigation (N = 143,461) explores how dispositional optimism-the generalized tendency to hold positive expectations about the future-shapes individuals' financial decisions and outcomes. Leveraging both cross-sectional and longitudinal designs across several countries, our findings reveal that optimism significantly predicts greater savings over time, even when controlling for various demographic, psychological, and financial covariates. Furthermore, we find that the role of optimism varies based on socioeconomic circumstances: Among lower income individuals, optimism is more strongly associated with saving.
View Article and Find Full Text PDF"Minimal-Advice" on Salt Intake: Results of a Multicentre Pilot Randomised Controlled Trial on Hypertensive Patients.
High Blood Press Cardiovasc Prev
January 2025
Department of Clinical Medicine and Surgery, ESH Excellence Center of Hypertension, "Federico II" University of Naples Medical School, Via S. Pansini, 5, 80131, Naples, Italy.
Introduction: A strong and well-known association exists between salt consumption, potassium intake, and cardiovascular diseases. MINISAL-SIIA results showed high salt and low potassium consumption in Italian hypertensive patients. In addition, a recent Italian survey showed that the degree of knowledge and behaviour about salt was directly interrelated, suggesting a key role of the educational approach.
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