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Promoter methylation of INK4a/ARF as detected in bile-significance for the differential diagnosis in biliary disease.
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Department of Internal Medicine I, University Hospital of Tübingen, Germany.
Purpose: There is a need to enhance endobiliary cytotechniques by molecular marker lesions. This is of special significance for patients with primary sclerosing cholangitis, a disease predisposing for the development of cholangiocarcinoma. The INK4a/ADP ribosylation factor (ARF) locus encodes two tumor suppressor genes: p16INK4a and p14ARF.
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