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Perinatal dysfunction of innate immunity in cystic fibrosis.
Sci Transl Med
January 2025
First Department of Medicine, Cardiology, TUM University Hospital, Technical University of Munich, School of Medicine and Health, Munich 81675, Germany.
In patients with cystic fibrosis (CF), repeated cycles of infection and inflammation eventually lead to fatal lung damage. Although diminished mucus clearance can be restored by highly effective CFTR modulator therapy, inflammation and infection often persist. To elucidate the role of the innate immune system in CF etiology, we investigated a CF pig model and compared these results with those for preschool children with CF.
View Article and Find Full Text PDFAsthma-related deaths in Brazil: data from an ecological study.
J Bras Pneumol
January 2025
. Departamento de Pneumologia, Hospital das Clínicas, Programa de Pós Graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia (GO), Brasil.
Objective: The aim of this study was to present epidemiological data on hospitalizations and deaths related to asthma in Brazil over the past 11 years.
Methods: An ecological study was conducted on asthma-related hospitalizations and mortality in Brazil from 2013 to 2023, using data extracted from the Department of Informatics of the Brazilian Unified Health System and the Mortality Information System.
Results: Asthma-related deaths showed an increasing trend during the analyzed period.
Respiratory virus detections in children presenting to an Australian paediatric referral hospital pre-COVID-19 pandemic, January 2014 to December 2019.
PLoS One
January 2025
Sydney Medical School, University of Sydney, Sydney, New South Wales (NSW), Australia.
Acute respiratory infections cause significant paediatric morbidity, but for pathogens other than influenza, respiratory syncytial virus (RSV), and SARS-CoV-2, systematic monitoring is not commonly performed. This retrospective analysis of six years of routinely collected respiratory pathogen multiplex PCR testing at a major paediatric hospital in New South Wales Australia, describes the epidemiology, year-round seasonality, and co-detection patterns of 15 viral respiratory pathogens. 32,599 respiratory samples from children aged under 16 years were analysed.
View Article and Find Full Text PDFFactors influencing health-related quality of life in children with asthma: insights from Addis Ababa public hospitals.
Front Public Health
January 2025
College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.
Background: Bronchial asthma is a global health problem in particular a respiratory condition characterized by broncho spasms that negatively affect the quality of life (QOL) of children. However, there is a paucity of data regarding the health-related quality of life of asthma in children in Ethiopia, and the study area.
Objective: The objective of this study was to assess the health-related quality of life among asthmatic children aged 7-17 in selected hospitals in Addis Ababa, Ethiopia.
A national cross-sectional study on latent profile analysis of occupational fatigue among Chinese nurses in the early post-COVID-19 era.
Front Public Health
January 2025
Department of Obstetric Nursing, West China Second University Hospital, Sichuan University, Chengdu, China.
Background: Occupational fatigue is a widespread condition within the nursing workforce, adversely affecting both nurses' health and patient safety. The protracted duration of the COVID-19 pandemic, approaching 3 years, has exacerbated the challenges faced by nurses globally. The escalation in patient numbers and the high incidence of infections among healthcare workers have intensified occupational fatigue.
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