The dissolution profile of mifentidine (CAS 83184-43-4), which is used as an antagonist of histamine at H2 receptors, was determined using a dissolution simulator. The use of an absorption simulator, which is designed to provide an estimate of the optimum sampling scheme for the dissolution simulator, provides useful data for this purpose. Various in vivo-in vitro correlations for mifentidine were examined and were found to be good.
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