The crossed thalamo-cortical and cortico-thalamic connections of the mouse are drawn using the tracer wheat germ agglutinin-horseradish peroxidase. After injections in the frontal cortex of the right hemisphere cells labeled retrogradely and axons labeled anterogradely are observed in the thalamus ipsilateral and contralateral to the cortical injections. The retrograde and anterograde labeling in the contralateral thalamus is less intense than ipsilaterally and involves the mediodorsal, ventral medial, central medial, and paracentral nuclei. Crossed fronto-thalamic axons reach more lateral regions than those containing contralateral thalamo-frontal neurons. Our results demonstrate that the thalamo-cortical system of mice has a bilateral component. The functional significance of this pathway and analogies with crossed thalamo-cortical connections in other species are discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0304-3940(96)12319-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Propranolol Reduces Parkinson's Tremor and Inhibits Tremor-Related Activity in the Motor Cortex: A Placebo-Controlled Crossover Trial.
Ann Neurol
December 2024
Department of Neurology, Centre of Expertise for Parkinson and Movement Disorders, Radboud University Medical Centre, Nijmegen, The Netherlands.
Objective: Parkinson's disease (PD) resting tremor is thought to be initiated in the basal ganglia and amplified in the cerebello-thalamo-cortical circuit. Because stress worsens tremor, the noradrenergic system may play a role in amplifying tremor. We tested if and how propranolol, a non-selective beta-adrenergic receptor antagonist, reduces PD tremor and whether or not this effect is specific to stressful conditions.
View Article and Find Full Text PDFDistinct white matter abnormalities and cognitive impairments in deficit schizophrenia: A cross-sectional diffusion tensor imaging study.
J Psychiatr Res
January 2025
Department of Geriatric Psychiatry, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 210029, China. Electronic address:
Deficit schizophrenia (DS), characterized by persistent and primary negative symptoms, is considered a promising homogeneous subtype of schizophrenia. According to the disconnection hypothesis, abnormalities in white matter fibers are common in schizophrenia. However, comprehensive measurement of white matter metrics and exploration of the relationships between neuroanatomical changes and cognitive functions in DS patients are still unknown.
View Article and Find Full Text PDFFunctional connectivity in complex regional pain syndrome: A bicentric study.
Neuroimage
November 2024
Functional Imaging Unit, Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Walther-Rathenau-Str. 46, Greifswald D-17475, Germany. Electronic address:
Article Synopsis
- The study examined brain connectivity in 51 CRPS patients compared to 50 control subjects, finding both weak and some specific differences in functional connectivity.
- It highlighted lower connectivity between the periaqueductal gray matter and the anterior insula, and higher connectivity within the reward system, indicating potential mechanisms in CRPS pain modulation.
- Importantly, the researchers observed lower data quality in CRPS patients, suggesting that findings on connectivity should be re-evaluated in future studies for better reliability.
Functional dysconnectivity of visual and somatomotor networks yields a simple and robust biomarker for psychosis.
Mol Psychiatry
October 2024
Department of Psychology, Yale University, 100 College St, New Haven, CT, 06510, USA.
Article Synopsis
- People with psychosis show distinct patterns of brain connectivity, indicating hyperconnectivity in thalamus-to-cortex pathways and reduced connections within sensory networks, but it’s unclear if this applies universally across all sensory networks.
- In a study involving 54 healthy individuals and 105 psychosis patients, researchers identified specific connectivity patterns in somatomotor and secondary visual networks that could serve as a reliable biomarker for psychosis, regardless of other clinical factors.
- This emerging "somato-visual" biomarker demonstrated strong discrimination between psychosis patients and controls, reliable test results, and the ability to differentiate between various stages of the illness, potentially aiding early diagnosis and intervention.
Tracking longitudinal thalamic volume changes during early stages of SCA1 and SCA2.
Radiol Med
August 2024
Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Purpose: Spinocerebellar ataxia SCA1 and SCA2 are adult-onset hereditary disorders, due to triplet CAG expansion in their respective causative genes. The pathophysiology of SCA1 and SCA2 suggests alterations of cerebello-thalamo-cortical pathway and its connections to the basal ganglia. In this framework, thalamic integrity is crucial for shaping efficient whole-brain dynamics and functions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!