In this paper I develop some observations on the methods used for therapeutic experiments with drugs in a psychiatric department. After a general introduction I deal with the following points. 1. The researcher confronted with the problem of intra- and inter-disciplinary collaboration. 2. The operators and the question of the choice of subjects. 3. Some aspects of the insurance and rewards in favor of the patient. 4. Remarks on the application phase. 5. Summarizing methodological proposals.
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