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Icaritin production from Epimedium folium extract by a one-pot enzymatic cascade of a multifunctional glycosidase and rhamnosidase.
Int J Biol Macromol
December 2024
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address:
Icaritin (ICT), a compound with diverse biological activities derived from Epimedium folium, is typically present in low concentrations in EFs. However, the abundant glycosyl-modified ICT compounds facilitate its transformation into ICT. Current biocatalytic production faces challenges, including low conversion rates and limited enzyme activity.
View Article and Find Full Text PDFDevelopment and testing of a resuscitation-specific measure of organizational culture for resuscitation teams.
Resusc Plus
December 2024
The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA, 19104, United States.
Background: The organizational culture (shared beliefs, perceptions, and values) of teams informs their behaviours and practices. Little is known about organizational culture for resuscitation teams. Our objective was to develop a reliable and valid resuscitation-specific organizational culture instrument (ROCI) with the goal of improving team performance.
View Article and Find Full Text PDFGenome-wide analysis of the soybean gene family and its involvement in virus resistance.
Front Plant Sci
August 2024
College of Grassland Science, Qingdao Agricultural University, Qingdao, China.
Eukaryotic elongation factors (eEFs) are protein factors that mediate the extension of peptide chain, among which eukaryotic elongation factor 1 alpha (eEF1A) is one of the most abundant protein synthesis factors. Previously we showed that the P3 protein of Soybean mosaic virus (SMV), one of the most destructive and successful viral pathogens of soybean, targets a component of the soybean translation elongation complex to facilitate its pathogenesis. Here, we conducted a systematic analyses of the soybean () gene family in soybean and examinedits role in virus resistance.
View Article and Find Full Text PDFRevealing eEF-2 kinase: recent structural insights into function.
Trends Biochem Sci
February 2024
Department of Chemistry and Biochemistry, The City College of New York, New York, NY 10031, USA; The Graduate Center of The City University of New York (CUNY), New York, NY 10016, USA. Electronic address:
The α-kinase eukaryotic elongation factor 2 kinase (eEF-2K) regulates translational elongation by phosphorylating its ribosome-associated substrate, the GTPase eEF-2. eEF-2K is activated by calmodulin (CaM) through a distinctive mechanism unlike that in other CaM-dependent kinases (CAMK). We describe recent structural insights into this unique activation process and examine the effects of specific regulatory signals on this mechanism.
View Article and Find Full Text PDFGreater resting frontal alpha asymmetry associated with higher emotional expressive flexibility.
Laterality
November 2023
College of Education Science and Technology, Nanjing University of Posts and Telecommunications, Nanjing, People's Republic of China.
Emotional expressive flexibility (EEF) is an important social ability that has prompted scholars to examine its benefits to human mental health. However, the neural underpinnings of individual differences in the EEF remain unclear. In neuroscience, frontal alpha asymmetry (FAA) is regarded as a sensitive indicator of certain emotional modalities and affective styles.
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