AI Article Synopsis
- A study examined the effects of preoperative irradiation on 29 patients with laryngeal carcinoma, using fast neutrons alone or alongside gamma therapy.
- Significant pathomorphosis was observed in all cases, including complete tumor disappearance in 2 patients, indicating a strong response to treatment.
- The degree of pathomorphosis was consistent regardless of tumor location, growth form, or level of spread, and no changes were noted in the larynx wall outside of the tumor area.
Article Abstract
Studies of tumours and adjacent tissue were carried out in 29 patients with carcinoma of the larynx after preoperative irradiation with fast neurons at a total focal dose 5.6 Gy alone or in combination with gamma therapy. Pronounced pathomorphosis was established in all the cases, up to a full disappearance of the tumor in 2 patients, the degree of pathomorphosis did not depend on location, macroscopic form of growth, degree of dissemination. No changes were found in the wall of the larynx outside the tumor.
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Article Synopsis
- A study examined the effects of preoperative irradiation on 29 patients with laryngeal carcinoma, using fast neutrons alone or alongside gamma therapy.
- Significant pathomorphosis was observed in all cases, including complete tumor disappearance in 2 patients, indicating a strong response to treatment.
- The degree of pathomorphosis was consistent regardless of tumor location, growth form, or level of spread, and no changes were noted in the larynx wall outside of the tumor area.
Histological material from 26 patients with laryngeal carcinoma was studied after surgery, photon and remote neutron-photon irradiation. The number of telophases in dividing tumor cells after the mixed irradiation was 1.5-3 times lower as compared to the surgical treatment.
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