The effect of a wild measles virus circulating in a childhood collective body on the immune status of 80 children has been studied over time. Only using enzyme immunoassay was it possible to fully record and assess the degree of booster effect of the virus on children in case of infection transmission. In 25% cases the increment of antibodies was at the expense of specific IgM antibodies appearing in the sera of children. By the end of the first month 60% of children developed a relative measles immunodepression. Analysis of the index of cell stimulation with phytohemagglutinin in the presence of suppressors enabled us to single out a group of children (30%) with weakly expressed suppressive factor. The observed phenomenon with a high degree of reliability may be used as an index of immune response development.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A systematic review of Aspilia africana (Pers.) C.D. adams traditional medicinal uses, phytoconstituents, bioactivities, and toxicities.
Pharmacol Res
January 2025
Korean Convergence Medical Science Major, Korea National University of Science and Technology (UST), Daejeon 34113, South Korea; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine (KIOM), 111 Geonjae-Ro, Naju-Si, South Korea. Electronic address:
Aspilia africana (Pers.) C. D.
View Article and Find Full Text PDFMultiplexed Detection, Partitioning, and Persistence of Wild-Type and Vaccine Strains of Measles, Mumps, and Rubella Viruses in Wastewater.
Environ Sci Technol
December 2024
Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005, United States.
Wastewater surveillance of vaccine-preventable diseases may provide early warning of outbreaks and identify areas to target for immunization. To advance wastewater monitoring of measles, mumps, and rubella viruses, we developed and validated a multiplexed RT-ddPCR assay for the detection of their RNA. Because the measles-mumps-rubella (MMR) vaccine is an attenuated live virus vaccine, we also developed an assay that distinguishes between wild-type and vaccine strains of measles in wastewater and validated it using a wastewater sample collected from a facility with an active measles outbreak.
View Article and Find Full Text PDFThe measles virus matrix F50S mutation from a lethal case of subacute sclerosing panencephalitis promotes receptor-independent neuronal spread.
J Virol
December 2024
Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Subacute sclerosing panencephalitis (SSPE) is a lethal neurological disorder occurring several years after measles. Reconstruction of the evolution of the measles virus (MeV) genome in an SSPE case suggested that the matrix (M) protein mutation M-F50S, when added to other mutations, drove neuropathogenesis. However, whether and how M-F50S would promote spread independently from other mutations was in question.
View Article and Find Full Text PDFSurveillance and agnostic capture sequencing of samples from individuals with rash-associated illness in Mali indicates regional transmission of measles virus from West and Central Africa.
Infect Genet Evol
December 2024
University Clinical Research Center (UCRC), Techniques, and Technologies of Bamako (USTTB), Bamako, Mali.
Measles is vaccine-preventable extremely contagious disease caused by the measles virus. High vaccination coverage is needed to prevent outbreaks of disease. Although molecular surveillance of measles is critical to characterize outbreaks and track viral evolution, few whole-genome sequences of measles virus from West Africa are available despite continual outbreaks in the region.
View Article and Find Full Text PDFStructure-based design of glycoprotein subunit vaccines for mumps.
Proc Natl Acad Sci U S A
November 2024
Vaccine Research Center, NIH, Bethesda, MD 20892.
Article Synopsis
- * Researchers developed a new subunit vaccine using a stabilized mumps fusion glycoprotein (Pre-F) and a chimeric immunogen, which showed strong immune responses in mice against various mumps genotypes.
- * The study identified specific antibodies against the Pre-F and hemagglutinin neuraminidase (HN), which could neutralize the virus effectively, suggesting these new immunogens could enhance existing vaccine-induced immunity or serve as improved vaccine options.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!