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Accuracy and user experience of dental diagnosis of a patient with cleidocranial dysplasia using immersive virtual reality and cone-beam computed tomography multiplanar reconstructions.
Am J Orthod Dentofacial Orthop
January 2025
School of Dentistry, University of Michigan, Ann Arbor, Mich.
Introduction: Accuracy and user experience of dental diagnosis for a patient with cleidocranial dysplasia (CCD) using immersive virtual reality (VR) and cone-beam computed tomography multiplanar reconstruction methods were evaluated.
Methods: Dental students (n = 40) were randomly assigned to VR or MP groups. VR participants manipulated and visualized the rendered 3-dimensional model using VR hardware and software.
-Acyl--alkyl/aryl Sulfonamide Chemistry Assisted by Proximity for Modification and Covalent Inhibition of Endogenous Proteins in Living Systems.
Acc Chem Res
January 2025
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
ConspectusSelective chemical modification of endogenous proteins in living systems with synthetic small molecular probes is a central challenge in chemical biology. Such modification has a variety of applications important for biological and pharmaceutical research, including protein visualization, protein functionalization, proteome-wide profiling of enzyme activity, and irreversible inhibition of protein activity. Traditional chemistry for selective protein modification in cells largely relies on the high nucleophilicity of cysteine residues to ensure target-selectivity and site-specificity of modification.
View Article and Find Full Text PDFUnlocking the potential: analyzing 3D microstructure of small-scale cement samples from space using deep learning.
NPJ Microgravity
January 2024
NASA Marshall Space Flight Center, Huntsville, 35808, AL, USA.
Due to the prohibitive cost of transporting raw materials into Space, in-situ materials along with cement-like binders are poised to be employed for extraterrestrial construction. A unique methodology for obtaining microstructural topology of cement samples hydrated in microgravity environment at the International Space Station (ISS) is presented here. Distinctive Scanning Electron Microscopy (SEM) micrographs of hardened tri-calcium silicate (CS) samples were used as exemplars in a deep learning-based microstructure reconstruction framework.
View Article and Find Full Text PDFConcept for gradient-free MRI on twin natural slices.
MAGMA
August 2023
Division of Biomedical Engineering and the quanTA Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Objective: The design of an MRI for use in space requires that the hardware be kept to an absolute minimum in terms of mass, complexity, and power. In addition, NASA requirements are that the external stray field needs to be less than 3.2 Gauss, 7 cm from the MRI enclosure.
View Article and Find Full Text PDFLongitudinal MRI-visible perivascular space (PVS) changes with long-duration spaceflight.
Sci Rep
May 2022
Division of Child Neurology, Department of Pediatrics, Doernbecher Children's Hospital, Oregon Health and Science University, 707 SW Gaines St., CDRC-P, Portland, OR, 97239, USA.
Humans are exposed to extreme environmental stressors during spaceflight and return with alterations in brain structure and shifts in intracranial fluids. To date, no studies have evaluated the effects of spaceflight on perivascular spaces (PVSs) within the brain, which are believed to facilitate fluid drainage and brain homeostasis. Here, we examined how the number and morphology of magnetic resonance imaging (MRI)-visible PVSs are affected by spaceflight, including prior spaceflight experience.
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