[Usefulness of transdermal hormone substitution in high risk postmenopausal patients].

The authors studied whether hormone replacement therapy can be performed in postmenopausal patients with high risk factors among anamnestic data such as thromboembolia, diabetes mellitus, hypertension, epilepsy. 50 mg 17 beta estradiol patch (twice weekly) and 10 mg medroxyprogesteron (in the last 12 days of the cycle) were prescribed. Data of 102 patients with the above conditions were analyzed at the beginning and at the 3,6, and 12 month follow-up visits. The frequency of exacerbation of anamnestic disease, biased and unbiased complaints, efficacy and side effects of the therapy were studied. In the authors opinion hormone replacement therapy can be safely performed in patients with high risk factors among anamnestic data, in addition it may be useful to prevent them.