We determined the complete amino acid sequences of two pituitary gonadotropins, follitropin and lutropin in the ostrich, thereby providing the first information on the structure of avian follitropin. Ostrich follitropin and lutropin both consist of two subunits: a common alpha-subunit and a hormone-specific beta-subunit. The alpha-subunit is composed of 96 amino acid residues and has 70-80% sequence identity with the alpha-subunits of most vertebrates. The ostrich follitropin beta-subunit consists of 106 amino-acid residues, and shows 70-74% sequence identity with mammalian follitropins beta, 61% with amphibian follitropin beta, 39-46% with teleost gonadotropins II beta and 32-44% with teleost gonadotropins I beta. The ostrich lutropin beta-subunit consists of 128 amino-acid residues, and exhibits 76-78% sequence identity with other avian lutropins beta, 44-50% with teleost gonadotropins II beta, 45% with amphibian lutropin beta, 41-44% with mammalian lutropins beta, and 25-36% with teleost gonadotropins I beta. Sequence comparison revealed that lutropin beta-subunits are more class-specific and have diversified approximately twice as fast follitropin beta-subunits, although segments essential for maintaining higher-order structures have been conserved.
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http://dx.doi.org/10.1111/j.1432-1033.1996.0262h.x | DOI Listing |
Comp Biochem Physiol A Mol Integr Physiol
January 2025
Neuroendocrinology Research Laboratory, Department of Studies in Zoology, Karnatak University, Dharwad 580 003, India. Electronic address:
This work aimed to investigate the response of cholecystokinin (CCK) to starvation and its impact on food intake and the reproductive axis of the tilapia Oreochromis mossambicus. The fish subjected to 21 days of starvation showed a significant decrease in CCK immunoreactivity in the hypothalamus, pituitary gland, and intestine. The administration of injections of 0.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
US Department of Agriculture, Agricultural Research Service, National Center for Cool and Cold Water Aquaculture, 11861 Leetown Road, Kearneysville, WV 25430, USA.
Gonadotropins and progestins are the primary regulators of follicle maturation and ovulation in fish, and they require complex communication among the oocyte and somatic cells of the follicle. The major progestin and the maturation-inducing hormone in salmonids is 17α,20β-dihdroxy-4-pregnen-3-one (17,20βP), and traditional nuclear receptors and membrane steroid receptors for the progestin have been identified within the follicle. Herein, RNA-seq was used to conduct a comprehensive survey of changes in gene expression throughout the intact follicle in response to in vitro treatment with these hormones to provide a foundation for understanding the coordination of their actions in regulating follicle maturation and preparation for ovulation.
View Article and Find Full Text PDFComp Biochem Physiol Part D Genomics Proteomics
December 2024
Department of Animal Biology, School of Life Sciences, University of Hyderabad, P.O. Central University, Hyderabad 500046, Telangana, India. Electronic address:
Endocrinology
October 2024
Institute of Marine & Environmental Technology, Department of Marine Biotechnology, University of Maryland Baltimore County, Baltimore, MD 21202, USA.
GnRH governs reproduction by regulating pituitary gonadotropins. Unlike most vertebrates, gnrh-/- zebrafish are fertile. To elucidate the role of the hypophysiotropic-Gnrh3 and other mechanisms regulating pituitary gonadotropes, we profiled the gene expression of all individual pituitary cells of wild-type and gnrh3-/- adult female zebrafish.
View Article and Find Full Text PDFComp Biochem Physiol A Mol Integr Physiol
October 2023
Fisheries Technology Institute Minamiizu Field Station, Japan Fisheries Research and Education Agency, 183-2 Irouzaki, Minamiizu, Kamo, Shizuoka 415-0156, Japan. Electronic address:
Pituitary gonadotropins, follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh), control oogenesis in all vertebrates. In particular, Lh plays a key role in stimulating the final oocyte maturation and subsequent ovulation. The biosynthesis and secretion of Lh are regulated by several neurohormones, including gonadotropin-releasing hormone (GnRH) and dopamine.
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