To investigate the possible role of absorbed amino acids in the "intestinal phase" of gastric secretion, experiments were carried out in 5 mongrel dogs with Heidenhain pouches, gastrostomies, and Roux en-Y jejunostomises. A 3% solution of mixed amino acids was infused at a constant rate of 120 ml per hr throughout a 2-hr period either intravenously or intrajejunally, and the secretory response of the pouches was compared to that obtained during similar infusions of 0.9% NaCl. Intravenous administration of saline did not stimulate gastric secretion. The mean secretory responses (muEq per 2 hr) were: intrajejunal saline 37, intravenous amino acids 330, and intrajejunal amino acids 301. These results suggest that amino acids, absorbed from the gut, may play a role in the stimulation of gastric secretion which occurs when food passes through the intestine.
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