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Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration.
Int J Mol Sci
October 2020
Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Cannabidiol (CBD) is a biologically active, non-psychotropic component of whose popularity has grown exponentially in recent years. Besides a wealth of potential health benefits, ingestion of CBD poses risks for a number of side effects, of which hepatotoxicity and CBD/herb-drug interactions are of particular concern. Here, we investigated the interaction potential between the cannabidiol-rich cannabis extract (CRCE) and methylsulfonylmethane (MSM), a popular dietary supplement, in the mouse model.
View Article and Find Full Text PDFInteraction of gamma-L-glutamyltaurine with kainate-induced cyclic AMP formation in the rat hippocampus.
Adv Exp Med Biol
March 1997
Tampere Brain Research Center, University of Tampere Medical School, Finland.
Interactions of gamma-L-glutamyltaurine with excitatory aminoacidergic neurotransmission.
Neurochem Res
March 1994
Department of Biomedical Sciences, University of Tampere, Finland.
The in vitro effects of gamma-L-glutamyltaurine on different stages of excitatory aminoacidergic neurotransmission were tested with gamma-D-glutamyltaurine as reference. gamma-L-Glutamyltaurine enhanced the K(+)-stimulated release of [3H]glutamate from cerebral cortical slices (25% at 0.1 mM) and slightly inhibited the uptake by crude brain synaptosomal preparations (about 10% at 1 mM).
View Article and Find Full Text PDFThe pharmacology of quisqualate and AMPA in the cerebral cortex of the rat in vitro.
Neuropharmacology
October 1989
Department of Pharmacology, School of Pharmacy, London, U.K.
The depolarising population response to the excitatory amino acids, quisqualate and AMPA, in slices of cerebral cortex of the rat have been compared. Their respective dose-response curves had a similar maximum but the slope of the curve for AMPA was consistently steeper than that for quisqualate. The dose-response curves for AMPA had a mean log EC50 of -5.
View Article and Find Full Text PDFInteractions of acoustic and somatosensory evoked responses in a polysensory cortex of the cat.
Acta Biol Hung
November 1988
Department of Comparative Physiology, József Attila University, Szeged, Hungary.
Interactions of acoustic and somatosensory evoked potentials were studied in the anterior suprasylvian gyrus of the cat. The interactions showed dynamic changes and were susceptible to different kinds of influences. The interactions could be influenced by synchronous activation of the acoustic and somatosensory inputs with 2 Hz frequency, or by elevating the stimulus frequency.
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