Two workers were poisoned following exposure to methyl iodide with inadequate protective devices. Their cases are presented together with a review of literature. Both patients developed symptoms and signs of cerebellar lesions and damage of the third, fourth, or sixth cranial nerve pathways. Spinal cord lesions producing motor and sensory disturbances were present in one. Late psychiatric disorders were observed in both patients. Although these symptoms were very similar to those reported in the nine published cases of methyl iodide poisoning, the toxicological diagnosis was delayed in one case: as repeated overexposure produced recurrent attacks of multifocal neurological dysfunction, multiple sclerosis was initially diagnosed, although several of the features observed are unusual in this disease. The manifestations of methyl iodide poisoning are similar to those of intoxication with other monohalomethanes. All these compounds probably share the same mechanisms of action. This mechanism and its therapeutic consequences are discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/(SICI)1097-0274(199612)30:6<759::AID-AJIM13>3.0.CO;2-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Determination of residual alkyl iodides and alkyl bromides as their corresponding alkyl chlorides in drug substances by headspace GC-FID.
Heliyon
December 2024
Curia Wisconsin, Inc. D/B/A Siegfried Acceleration Hub, 870 Badger Circle, Grafton, WI, 53024, United States.
Primary and secondary alkyl iodides and primary alkyl bromides were quickly and conveniently converted into their corresponding alkyl chlorides via S2 halide-halide substitution. The resultant alkyl chlorides simultaneously demonstrated increased volatility and stability paired with standard headspace GC-FID methodology. The derivatization was performed on both standard and sample alike and occurred during the headspace oven equilibration phase, eliminating the extra reaction step traditionally performed during many derivatization analyses.
View Article and Find Full Text PDFSynthesis of Rigid Stepladder Polymers Scandium-Catalyzed Polyspiroannulation of Quinoline with Alkyne.
J Am Chem Soc
January 2025
Advanced Catalysis Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Article Synopsis
- The study focuses on the development of a new type of rigid, three-dimensional polymers known as stepladder polymers, utilizing spirodihydroquinoline structures.
- These polymers are created through a reaction facilitated by a scandium catalyst that activates specific chemical bonds, allowing for the formation of complex structures from quinoline and alkyne compounds.
- The resulting polymers have increased thermal stability and porosity after undergoing a treatment that adds a methyl group to their nitrogen-containing functional groups.
Evaluation of Quinazolin-2,4-Dione Derivatives as Promising Antibacterial Agents: Synthesis, In Vitro, In Silico ADMET and Molecular Docking Approaches.
Molecules
November 2024
Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt.
A series of new quinazolin-2,4-dione derivatives incorporating amide/eight-membered nitrogen-heterocycles -, in addition, acylthiourea/amide/dithiolan-4-one and/or phenylthiazolidin-4-one - and -. The starting compound was prepared by reaction of 4-(2,4-dioxo-1,4-dihydro-2-quinazolin-3-yl)-benzoyl chloride with ammonium thiocyanate and cyanoacetic acid hydrazide. The reaction of with strong electrophiles, namely, -aminophenol, -amino thiophenol, and/or -phenylene diamine, resulted in corresponding quinazolin-2,4-dione derivatives incorporating eight-membered nitrogen-heterocycles -.
View Article and Find Full Text PDFTask-Driven Tailored Covalent Organic Framework for Dynamic Capture of Trace Radioactive CH I under High-Flow Rate Conditions.
ACS Cent Sci
November 2024
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China.
Article Synopsis
- The removal of radioactive gaseous iodine, especially methyl iodide, is essential for safe nuclear energy management and waste disposal, but effective capture methods are still being researched.* -
- This study used a "theory-first" approach to create a new material, piperazine-based covalent organic framework (Pip-COF), designed specifically for high capture efficiency of methyl iodide.* -
- Testing showed Pip-COF performs exceptionally well, capturing up to 39 mg/g at 75 °C and 78 mg/g at 25 °C, far exceeding previous materials, and the study highlights the importance of rational design in addressing environmental challenges.*
Imidazole Encapsulation Enabled by Confinement for I and CHI Coremoval.
Inorg Chem
December 2024
National Co-Innovation Center for Nuclear Waste Disposal and Environmental Safety, Southwest University of Science and Technology, Mianyang 621010, China.
Nitrogen-rich small molecules are frequently doped into porous materials to enhance their iodine adsorption properties. To explore how imidazole confinement in metal-organic frameworks (MOFs) affects iodine adsorption, we obtained a UiO-66-based composite by embedding imidazole in UiO-66 pores via solid-phase adsorption (Im@UiO-66). Characterization confirmed that imidazole was successfully confined within the UiO-66 pores, with each unit of UiO-66 accommodating up to 27 imidazole molecules.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!