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Tumor necrosis factor-alpha inhibitors may increase the need for fine-needle aspiration cytology in axial spondyloarthritis patients.
Rev Assoc Med Bras (1992)
December 2024
Gaziantep University, School of Medicine, Department of Endocrinology and Metabolism - Gaziantep, Turkey.
Objective: Tumor necrosis factor alpha inhibitors are frequently used in the treatment of axial spondyloarthritis. While tumor necrosis factor alpha is associated with some malignancies, studies on its effects on thyroid functions and thyroid nodules are limited. This study aimed to assess the effect of tumor necrosis factor alpha inhibitors treatments on the evaluation of thyroid nodules and thyroid function tests in axial spondyloarthritis patients.
View Article and Find Full Text PDFMining and analysis of adverse event signals of vandetanib based on the FAERS database.
Expert Opin Drug Saf
October 2024
Department of Pharmacy, Kunming Third People's Hospital/Department of Pharmacy, Yunnan Provincial Center for Clinical Pharmacy and Infectious Diseases, Kunming, Yunnan, China.
Objective: By analyzing the signal mining of vandetanib AEs, it provides a reference for the rational clinical use of the drug.
Methods: This study provides signal detection and analysis of AEs associated with vandetanib using the FAERS from Q2 2011 to Q1 2023.
Results: Disproportionality analyses were conducted using the ROR and the MHRA method, with AEs categorized and described based on SOC and PT from the MedDRA.
[Medical clinical diagnostics for indoor mould exposure - Update 2023 (AWMF Register No. 161/001)].
Pneumologie
October 2024
Labor Dr. Wisplinghoff.
This article is an abridged version of the updated AWMF mould guideline "Medical clinical diagnostics in case of indoor mould exposure - Update 2023", presented in July 2023 by the German Society of Hygiene, Environmental Medicine and Preventive Medicine (Gesellschaft für Hygiene, Umweltmedizin und Präventivmedizin, GHUP), in collaboration with German and Austrian scientific medical societies, and experts. Indoor mould growth is a potential health risk, even if a quantitative and/or causal relationship between the occurrence of individual mould species and health problems has yet to be established. There is no evidence for a causal relationship between moisture/mould damage and human diseases, mainly because of the ubiquitous presence of fungi and hitherto inadequate diagnostic methods.
View Article and Find Full Text PDFRapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
Genetic Analyses in a Cohort of Pediatric Patients with Congenital Hypothyroidism Based on Congenital Hypothyroidism Consensus Guideline.
Horm Res Paediatr
October 2024
Department of Pediatric Endocrinology, Erzurum City Hospital, University of Health Sciences, Erzurum, Turkey.
Article Synopsis
- The study focused on congenital hypothyroidism (CH) and aimed to analyze the clinical and genetic factors associated with it, specifically targeting genetic variants linked to thyroid tissue formation and hormone secretion.
- A total of 61 Turkish patients from 45 families participated, with a variant detection rate of 37.7%; the most common mutations were found in the TPO gene, followed by TSHR, DUOX2, TG, and NKX2-1 genes.
- The research identified rare new gene variations related to CH, suggesting that the current guidelines for genetic analysis are effective, and highlighting the potential prevalence of TSHR mutations in thyroid dysgenesis cases.
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