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Orthotopic liver/small bowel transplantation in rats: a microsurgical model inducing tolerance.
Microsurgery
October 2001
Department of Surgery, University of Würzburg, Josef-Schneider Strasse 2, D-97080 Würzburg, Germany.
Liver cirrhosis in patients with short bowel syndrome is successfully treated in humans by simultaneous liver/small bowel transplantation. However, until now, a clinically relevant experimental rat model for this procedure has not existed. We therefore established a protocol that, for the first time in rats, allows the simultaneous transplantation of arterialized liver and small bowel into an orthotopic position.
View Article and Find Full Text PDFCombined orthotopic liver-small bowel transplantation or small bowel transplantation in pigs: relations between survival, rejection, and mucosal morphometry.
Transplant Proc
May 1997
Cattedra di Gastroenterologia, Istituto di Scienze Mediche, Milan, Italy.
Investigations of the immunoprotective role of the liver after allogeneic orthotopic combined liver-small-bowel transplantation in the rat.
Transplant Proc
April 1997
Department of Surgery, University of Würzburg, Germany.
[Technique for protecting the liver graft less tolerant than the small bowel to heat-induced ischemia in experimental liver + small bowel transplantation in swine].
Chirurgie
August 1998
Faculté de Médecine de Poitiers, Service de Chirurgie Viscérale, Hôpital J.-Bernard.
Multivisceral and orthotopic liver/small bowel transplantations have been performed to treat patients with intestinal failure associated with liver failure induced by parenteral nutrition. The aim of this experimental study was to determine the experimental liver-small bowel harvesting and transplantation technique that achieves the best compromise between liver and intestine ischemia times in pigs. Initial portal revascularization of the liver which reduces the hepatic warm ischemia time after cold ischemia preparation of the graft immersed in lactated ringer's solution at 4 degrees C, reduce the risk of primary non function of the graft.
View Article and Find Full Text PDFMain complications in an experimental study of orthotopic liver-small bowel transplantation in the pig.
Transplant Proc
October 1996
Istituto di Chirurgia Sperimentale e dei Trapianti, Università degli Studi di Milano, Ospedale Maggiore di Milano I.R.C.C.S., Italy.
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