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Fecal metabolomic analysis of the role of gut microbiota and short-chain fatty acids in the therapeutic mechanism of Timosaponin AIII in Sjögren's syndrome.
Clin Rheumatol
January 2025
Department of Rheumatology, Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
Introduction/objectives: Sjogren's syndrome (SS) is a chronic inflammatory and difficult-to-treat autoimmune disease. Timosaponin AIII (TAIII), a plant-derived steroidal saponin, effectively inhibits cell proliferation, induces apoptosis, and exhibits anti-inflammatory properties. This study explored the mechanisms of action of TAIII in SS treatment by studying gut microbiota and short-chain fatty acids (SCFAs) using fecal metabolomics.
View Article and Find Full Text PDFIL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis.
Inflamm Res
January 2025
Department of Otolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China.
Background: Allergic rhinitis (AR) represents a persistent inflammatory condition affecting the upper respiratory tract, characterized by abnormal initiation of the immunoglobulin E (IgE)-mediated cascade. Follicular helper T (Tfh) cells and regulatory T (Tfr) cells are pivotal in orchestrating the development of IgE production in AR patients. IL-35, an anti-inflammatory cytokine, secreted by various cellular subpopulations.
View Article and Find Full Text PDFLand use and cover changes and sand fly (Diptera: Psychodidae) assemblages in an emerging focus of leishmaniasis.
Med Vet Entomol
January 2025
Department of Chemistry and Biology, Universidade Estadual do Maranhão, Caxias, Brazil.
Land use and cover changes lead to fragmentation of the natural habitats of sand flies and modify the epidemiological profile of leishmaniasis. This process contributes to the infestation of adjacent rural settlements by vector sand fly species with different degrees of adaptation, promoting leishmaniasis outbreaks. This study aimed to assess land use and cover changes over a 12-year period and investigate the diversity and abundance of sand fly assemblages in the rural area of Codó, Maranhão State, Brazil.
View Article and Find Full Text PDFDoes Perfectionism Affect Parental Identity Development? A One-Year Longitudinal Study.
J Pers
January 2025
Self and Identity Development Laboratory, Department of Psychology, Babes-Bolyai University, Cluj-Napoca, Romania.
Introduction: Previous studies have revealed that perfectionism and identity development during adolescence are related. However, no longitudinal study has been conducted on the impact of perfectionism on identity development in adulthood. In the present study, we analyzed for the first time the longitudinal relationship between personal standards, an indicator of perfectionistic strivings, and concern over mistakes and doubts about actions, indicators of perfectionist concerns, and identity development in one of the most important yet least understood domains for adults, parental identity.
View Article and Find Full Text PDFVGX: VGG19-Based Gradient Explainer Interpretable Architecture for Brain Tumor Detection in Microscopy Magnetic Resonance Imaging (MMRI).
Microsc Res Tech
January 2025
AIDA Lab. College of Computer and Information Sciences (CCIS), Prince Sultan University, Riyadh, Saudi Arabia.
The development of deep learning algorithms has transformed medical image analysis, especially in brain tumor recognition. This research introduces a robust automatic microbrain tumor identification method utilizing the VGG16 deep learning model. Microscopy magnetic resonance imaging (MMRI) scans extract detailed features, providing multi-modal insights.
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