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Modeling of Jet Lag and Searching for an Optimal Light Treatment.
J Biol Rhythms
January 2025
Department of Physics and i3n, University of Aveiro, Aveiro, Portugal.
The role of the hierarchical organization of the suprachiasmatic nucleus (SCN) in its functioning, jet lag, and the light treatment of jet lag remains poorly understood. Using the core-shell model, we mimic collective behavior of the core and shell populations of the SCN oscillators in transient states after rapid traveling east and west. The existence of a special region of slow dynamical states of the SCN oscillators can explain phenomena such as the east-west asymmetry of jet lag, instances when entrainment to an advance is via delay shifts, and the dynamics of jet lag recovery time.
View Article and Find Full Text PDFThe contribution of clock genes BMAL1 and PER2 in osteoarthritis-associated pain.
Neurobiol Pain
December 2024
Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL, USA.
Joint pain is the primary symptom of osteoarthritis (OA) and the main motivator for patients to seek medical care. OA-related pain significantly restricts joint function and diminishes quality of life. Despite the availability of various pain-relieving medications for OA, current treatment strategies often fall short in delivering adequate pain relief.
View Article and Find Full Text PDFAdverse childhood experiences and diurnal cortisol pattern and heart rate variability in adults.
Psychoneuroendocrinology
January 2025
School of Sport, Exercise and Health Sciences, Loughborough University, United Kingdom.
Dysregulation of hypothalamic-pituitary-adrenal axis (HPA axis) and of the autonomic nervous system may link stress throughout the life course with poorer health. This study aims to investigate whether multiple adverse childhood experiences have a long-term impact on markers of these systems - cortisol secretion and heart rate variability - in adulthood. Data were from the Whitehall II cohort study.
View Article and Find Full Text PDFEmergent robust oscillatory dynamics in the interlocked feedback-feedforward loops.
IET Syst Biol
January 2025
Center for Computational Biology, Department of Computational Biology, IIIT-Delhi, New Delhi, India.
One of the challenges that beset modelling complex biological networks is to relate networks to function to dynamics. A further challenge is deciphering the cellular function and dynamics that can change drastically when the network edge is tinkered with by adding or removing it. To illustrate this, the authors took a well-studied three-variable Goodwin oscillatory motif with only a negative feedback loop.
View Article and Find Full Text PDFComprehensive Analysis Reveals the Potential Diagnostic Value of Biomarkers Associated With Aging and Circadian Rhythm in Knee Osteoarthritis.
Orthop Surg
January 2025
Department of Orthopedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin, China.
Objective: Knee osteoarthritis (KOA) is characterized by structural changes. Aging is a major risk factor for KOA. Therefore, the objective of this study was to examine the role of genes related to aging and circadian rhythms in KOA.
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