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On the Biosynthesis of Bioactive Tryptamines in Black Cohosh ( L.).
Plants (Basel)
January 2025
Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD 20850, USA.
Botanical dietary supplements are widely used, but issues of authenticity, consistency, safety, and efficacy that complicate their poorly understood mechanism of action have prompted questions and concerns in the popular and scientific literature. Black cohosh ( L., syn.
View Article and Find Full Text PDFMetabolomics and Transcriptomics Reveal the Effects of Different Fermentation Times on Antioxidant Activities of .
J Fungi (Basel)
January 2025
State Key Laboratory of Plateau Ecology and Agriculture, Qinghai Academy of Animal and Veterinary Science, Qinghai University, Xining 810016, China.
is a fungus that is cultured through fermentation from wild Chinese cordyceps. While studies have examined its metabolites, the evaluation of its antioxidant capacity remains to be conducted. The antioxidant results of indicate that the ferric ion-reducing antioxidant power (FRAP), antioxidant capacity (2.
View Article and Find Full Text PDFOral vancomycin treatment alters levels of indole derivatives and secondary bile acids modulating the expression of mTOR pathway genes in astrocytes during EAE.
Brain Behav Immun
January 2025
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:
Astrocytes play important roles in the central nervous system (CNS) during health and disease. Prior studies have shown that gut commensal-derived indole derivatives as well as secondary bile acids modulate astrocyte function during the late stage of EAE (recovery phase). Here we showed that administering vancomycin to mice starting during the early stage of EAE improved disease recovery, an effect that is mediated by the gut microbiota.
View Article and Find Full Text PDFThe Complex Energy Landscape of miRFP709, a 4-Knotted Protein, Results in Its Irreversible Denaturation.
J Phys Chem B
January 2025
Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India.
Knotted proteins have a unique topological feature with an open knot, and the physiological significance of these knots remains elusive. In addition, these proteins challenge our understanding of the protein folding process, and whether they retain their native state during unfolding/refolding cycles like other proteins is debated. Most folding studies on knotted proteins have been performed on 3 and 5 knots, monitoring the tryptophan fluorescence.
View Article and Find Full Text PDFSpectroscopic Methods for Detecting Conformational Changes During Sec18-Lipid Interactions.
Methods Mol Biol
January 2025
Estrella Mountain Community College, Phoenix, AZ, USA.
Vacuole fusion is driven by SNARE proteins that require activation-or priming-by the AAA+ protein Sec18 (NSF) before they can bring membranes together and trigger the merger of two bilayers into a continuous membrane. Sec18 resides on vacuoles prior to engaging inactive cis-SNARE complexes through its interaction with the regulatory lipid phosphatidic acid (PA). Binding PA causes Sec18 to undergo large conformational changes that keeps it bound to the membrane, thus precluding its interactions with SNAREs.
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