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Advanced Peptide Nanozymes with Dual Antifungal Mechanisms: Cutting-Edge Innovations in Combatting Antimicrobial Resistance.
Curr Microbiol
January 2025
Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Poonamallee High Road, Chennai, Tamil Nadu, 600 077, India.
This letter commends the recent innovative research findings on "Dual-Action Antifungal Peptide Nanozymes: A Novel Approach to Combatting Antimicrobial Resistance." The study introduces a pioneering method to address antimicrobial resistance by developing peptide nanozymes that mimic antimicrobial peptides and enzymes through de novo design and peptide assembly. The heptapeptide IHIHICI, designed using AlphaFold2 and molecular dynamics simulations, exhibits high stability and dual antifungal actions, effectively killing over 90% of Candida albicans within 10 min.
View Article and Find Full Text PDFMicrobial indicators for water quality in recirculating shower technology.
Sci Total Environ
January 2025
Technical University of Denmark, DTU Sustain, Bygningstorvet, Building 115, 2800 Kg. Lyngby T. Pérez Guillemette, Denmark. Electronic address:
Recirculating showers save up to 70-80 % of the water and energy use of conventional showers, but water quality in these systems are not studied very well due to the technology's early stages. The aim of this study was to provide an overview of information available on which microorganisms were investigated and at which densities. Based on this platform we further aimed at identifying key microbial indicators and pathogens for monitoring water quality in these systems by integrating data from the top five waterborne outbreaks with findings from studies on (1) microbial investigations in reuse projects involving shower effluents or combined bathroom streams, (2) shower water effluents, and (3) biofilms in conventional showers.
View Article and Find Full Text PDFCdr1 in focus: a personal reflection on multidrug transporter research.
FEMS Yeast Res
January 2025
Amity Institute of Integrative Science and Health, Amity University Haryana, Gurugram, 122413, India.
Drug resistance mechanisms in human pathogenic Candida species are constantly evolving. Over time, these species have developed diverse strategies to counter the effects of various drug classes, making them a significant threat to human health. In addition to well-known mechanisms such as drug target modification, overexpression, and chromosome duplication, Candida species have also developed permeability barriers to antifungal drugs through reduced drug import or increased efflux.
View Article and Find Full Text PDFInnovative antifungal strategies: enhanced biofilm inhibition of by a modified tea tree oil formulation.
Front Microbiol
January 2025
Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Prague, Czechia.
Introduction: is a significant human pathogen with the ability to form biofilms, a critical factor in its resistance to antifungal treatments. This study aims to evaluate the antifungal activity and biofilm inhibition potential of Tea Tree Oil (TTO) derived from cultivated in Vietnam.
Methods: The antifungal activity of TTO was assessed by determining the Minimum Inhibitory Concentration (MIC), Minimum Fungicidal Concentration (MFC), Minimum Biofilm Inhibitory Concentration (MBIC), and Minimum Biofilm Eradication Concentration (MBEC) using broth dilution methods.
Comparative Analysis of In-House and Commercially Available Media for Determining the Antifungal Susceptibility Profile of Candida Species.
Cureus
December 2024
Department of Microbiology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed To Be University), Karad, IND.
Background The emergence of treatment-resistant species has highlighted the importance of antifungal susceptibility testing as it is difficult to determine therapeutics solely based on species identification. However, as compared to bacterial pathogens, antimicrobial susceptibility testing in fungi still remains underutilized in most clinical diagnostic microbiological services. The disc diffusion (DD) technique is reported to be easy and cost-effective and therefore can be easily incorporated as a routine method.
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