AI Article Synopsis
- Two cases of severe nontyphoidal salmonellosis (specifically Salmonella enteritidis) were reported in patients who began treatment with Omeprazole (20 mg daily) just 4 and 5 weeks prior.
- Neither patient had any family members who were ill, nor had they eaten outside their homes in the two weeks before symptoms appeared.
- The study highlights that reduced gastric acid (hypochlorhydria) significantly increases the risk of Salmonella infections, which can lead to more severe clinical outcomes.
Article Abstract
We report 2 cases of severe nontyphoidal salmonellosis (Salmonella enteritidis), occurring 4 and 5 weeks after starting a treatment with Omeprazole (20 mg a day). No other member of the families was sick, and none of the 2 patients took any meals outside home during the two weeks preceding the first symptoms. Gastric hypochlorhydria is a major risk factor for Salmonella enteritidis, and several cases of severe infection have been described with this condition. After a review of the literature we conclude that patients with diminished gastric acid run an increased risk of developing Salmonella infection and often with a more serious clinical course.
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