AI Article Synopsis
- A study analyzed mutation patterns in 16 patients with glutaric aciduria type I (GA-I) from eight families in Israel.
- Researchers sequenced the glutaryl-CoA dehydrogenase gene and discovered seven new mutations across 15 alleles, including various point mutations and a 1-bp deletion.
- The findings suggest that the mutations may arise from recent origins in isolated communities with high rates of intermarriage, but they do not clarify the clinical variability observed in GA-I cases.
Article Abstract
Mutation analysis was performed in eight families (16 patients) with glutaric aciduria type I (GA-I), which were all the families diagnosed in Israel in the years 1987-1994. Six families were of Moslem origin and two were non-Ashkenazi Jews. The entire coding region of the cDNA of the glutaryl-CoA dehydrogenase gene was sequenced in one patient of each family. Seven new mutations were identified in 15 of 16 mutated alleles, including six point mutations: T416I (4 alleles), G390R (1 allele), and S305L, A293T, L283P, and G1O1R (2 alleles each). In addition, a 1-bp deletion at position 1173 was identified in two alleles. These findings do not provide a molecular basis for the clinical variability in GA-I families. The occurrence of multiple novel mutations in a small geographic area may be explained by their recent onset in isolated communities with a high consanguinity rate.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914820 | PMC |
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