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The Double-Stranded RNA Binding Proteins DRB1 and DRB2 Are Required for miR160-Mediated Responses to Exogenous Auxin.
Genes (Basel)
December 2024
Seaweed Research Group, School of Health, University of the Sunshine Coast, Maroochydore, QLD 4558, Australia.
DOUBLE-STRANDED RNA BINDING (DRB) proteins DRB1, DRB2, and DRB4 are essential for microRNA (miRNA) production in () with miR160, and its target genes, (), , and , forming an auxin responsive miRNA expression module crucial for root development. : Wild-type plants (Columbia-0 (Col-0)) and the , , and mutants were treated with the synthetic auxin 2,4-dichlorophenoxyacetic acid (2,4-D), and the miR160-mediated response of these four lines was phenotypically and molecularly characterized. : In 2,4-D-treated Col-0, and plants, altered miR160 abundance and , , and gene expression were associated with altered root system development.
View Article and Find Full Text PDFDRB1, DRB2 and DRB4 Are Required for an Appropriate miRNA-Mediated Molecular Response to Osmotic Stress in .
Int J Mol Sci
November 2024
Seaweed Research Group, School of Health, University of the Sunshine Coast, Maroochydore, QLD 4558, Australia.
() double-stranded RNA binding (DRB) proteins DRB1, DRB2 and DRB4 perform essential roles in microRNA (miRNA) production, with many of the produced miRNAs mediating aspects of the molecular response of to abiotic stress. Exposure of the , and mutants to mannitol stress showed to be the most sensitive to this form of osmotic stress. Profiling of the miRNA landscapes of mannitol-stressed , and seedlings via small RNA sequencing, and comparison of these to the profile of mannitol-stressed wild-type plants, revealed that the ability of the and mutants to mount an appropriate miRNA-mediated molecular response to mannitol stress was defective.
View Article and Find Full Text PDFCharacterisation of the novel HLA-DRB4*01:182 allele by sequencing-based typing.
HLA
July 2024
Histocompatibility and Immunogenetics Laboratory, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.
HLA-DRB4*01:182 differs from HLA-DRB4*01:03:01:01 by one nucleotide substitution in codon 172 in exon 3.
View Article and Find Full Text PDFOral Insulin Delay of Stage 3 Type 1 Diabetes Revisited in HLA DR4-DQ8 Participants in the TrialNet Oral Insulin Prevention Trial (TN07).
Diabetes Care
September 2024
Department of Clinical Sciences, Lund University CRC, Skåne University Hospital, Malmö, Sweden.
Article Synopsis
- The study aimed to investigate whether oral insulin can postpone the onset of stage 3 type 1 diabetes (T1D) in patients who have stage 1 or 2 T1D and specific genetic markers (HLA DR4-DQ8) or elevated IA-2 autoantibodies.
- Researchers used advanced genetic testing on 546 participants to analyze the connection between genetic factors and autoantibody levels prior to treatment, utilizing Cox regression to assess the effectiveness of oral insulin.
- Findings revealed that oral insulin significantly decreased the T1D onset in participants with high IA-2A levels, particularly among those carrying the HLA DR4-DQ8 haplotype, indicating a specific endotype of T1D
Characterisation of the novel HLA-DRB4*01:01:12 allele by sequencing-based typing.
HLA
May 2024
Laboratoire d'Immunologie et Immunogénétique, Hôpital Pellegrin, CHU de Bordeaux, Bordeaux, France.
HLA-DRB4*01:01:12 differs from HLA-DRB4*01:01:01:01 by one nucleotide substitution in codon 175 in exon 3.
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