Recent reports suggest that transient neurologic symptoms are common after spinal anesthesia with 5% lidocaine. To determine whether reducing the anesthetic concentration might decrease the incidence of symptoms, 50 ASA class I or II patients undergoing brief gynecologic procedures under spinal anesthesia were randomly allocated to receive 1 mg/kg of either 5% or 2% lidocaine in 7.5% glucose. Patients were evaluated on the first postoperative day by an anesthesiologist who was unaware of the solution administered or the details of the anesthetic procedure. Symptoms suggestive of transient radicular irritation were observed in 8 patients (32%) receiving 5% lidocaine, and in 10 patients (40%) receiving 2% lidocaine (NS). These results confirm our previous findings that transient neurologic symptoms may occur in up to one third of the patients receiving 5% lidocaine, and indicate that a modest reduction in lidocaine concentration does not reduce risk.

Download full-text PDF

Source
http://dx.doi.org/10.1097/00000539-199611000-00026DOI Listing

Publication Analysis

Top Keywords

transient neurologic
12
neurologic symptoms
12
spinal anesthesia
12
receiving lidocaine
12
anesthesia lidocaine
8
lidocaine
7
symptoms
5
patients
5
incidence transient
4
symptoms spinal
4

Similar Publications

Whether working memory (WM) is encoded by persistent activity using attractors or by dynamic activity using transient trajectories has been debated for decades in both experimental and modeling studies, and a consensus has not been reached. Even though many recurrent neural networks (RNNs) have been proposed to simulate WM, most networks are designed to match respective experimental observations and show either transient or persistent activities. Those few which consider networks with both activity patterns have not attempted to directly compare their memory capabilities.

View Article and Find Full Text PDF

Radiofrequency-thermocoagulation in pediatric epilepsy surgery: A systematic review and pooled analysis of cases.

Seizure

January 2025

Department of Clinical Neurological Sciences, Western University, London, ON. Canada; Department of Paediatrics, Western University, London, ON. Canada. Electronic address:

Objective: To conduct a systematic review on radiofrequency thermocoagulation (RF-TC) in pediatric epilepsy surgery. In addition, due to the low number of dedicated pediatric series, to conduct a pooled analysis of cases published in the literature.

Methods: We conducted a literature search using PUBMED and EMBASE which produced 432 results.

View Article and Find Full Text PDF

Several neurological conditions, including transient global amnesia (TGA), may present an isolated sudden-onset temporary amnestic symptom. TGA is a benign, self-remitting neurological condition associated with hippocampal dysfunction. Meanwhile, certain other neurological conditions, such as cerebral ischemic stroke and hippocampal epilepsy, require appropriate therapeutic interventions.

View Article and Find Full Text PDF

Delayed radiation-induced brain injury (RIBI) characterized by progressive cognitive decline significantly impacts patient outcomes after radiotherapy. The activation of NLRP3 inflammasome within microglia after brain radiation is involved in the progression of RIBI by mediating inflammatory responses. We have previously shown that sulfonylurea receptor 1-transient receptor potential M4 (SUR1-TRPM4) mediates microglial NLRP3-related inflammation following global brain ischemia.

View Article and Find Full Text PDF

The L-type Ca channel (Ca1.2) is essential for cardiac excitation-contraction coupling. To contribute to the inward Ca flux that drives Ca-induced-Ca-release, Ca1.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!