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The Landscape of Helicobacter pylori-related Gastric Carcinogenesis.
J Gastrointestin Liver Dis
December 2024
Department of Medicine, Pathology Unit, University of Padua, Padova 35121, Italy; Veneto Tumor Registry, Padova, Italy.
The relationship between Helicobacter pylori (H. pylori) and humans remains a complex enigma. While other factors contribute to gastric cancer (GC), their impact pales in comparison to the central role of H.
View Article and Find Full Text PDFPossible viral agents to consider in the differential diagnosis of blepharoconjunctivitis.
World J Virol
December 2024
Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy.
Background: Blepharoconjunctivitis poses a diagnostic challenge due to its diverse etiology, including viral infections. Blepharoconjunctivits can be acute or chronic, self-limiting, or needing medical therapy.
Aim: To review possible viral agents crucial for accurate differential diagnosis in cases of blepharoconjunctivitis.
Role of viruses in periodontitis: An extensive review of herpesviruses, human immunodeficiency virus, coronavirus-19, papillomavirus and hepatitis viruses.
World J Virol
December 2024
Department of Biomedical Science, University of Denver, Denver, CO 80014, United States.
Periodontitis is the inflammation of the supporting structures around the dentition. Several microbial agents, mostly bacteria, have been identified as causative factors for periodontal disease. On the other hand, oral cavity is a rich reservoir for viruses since it contains a wide variety of cell types that can be targeted by viruses.
View Article and Find Full Text PDFDistinct genomic features of Transeurasian strains of Epstein-Barr virus in East Asia.
Virology
December 2024
Division of Microbiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan. Electronic address:
More than 95% of adult humans worldwide are latently infected with Epstein-Barr virus (EBV). Recent studies indicated that different EBV strains colonize different regions of Asia, where nasopharyngeal carcinoma (NPC) is endemic (southern China) or non-endemic (Japan/Korea). We searched for viral single nucleotide variant markers throughout the EBV genome by comparing the coding sequences of Japanese/Korean and NPC-endemic Chinese strains.
View Article and Find Full Text PDFThe role of MAPK pathway in gastric cancer: unveiling molecular crosstalk and therapeutic prospects.
J Transl Med
December 2024
Department of General Surgery, The Lu'an Affiliated Hospital of Anhui Medical University, Lu'an People's Hospital, Lu'an, 237000, China.
Gastric cancer remains a significant health burden globally, especially prevalent in Asian and European regions. Despite a notable decline in incidence in the United States and Western Europe over recent decades, the disease's persistence underscores the urgency for advanced research in its pathogenesis and treatment strategies. Central to this pursuit is the exploration of the mitogen-activated protein kinase (MAPK) pathway, a pivotal cellular mechanism implicated in the complex processes of gastric cancer development, including cellular proliferation, invasion, migration, and metastasis.
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