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3D-Bioprinted Urinary Catheters Enable Sustained Probiotic Recovery Under Flow and Improve Bladder Colonization In Vivo.
Probiotics Antimicrob Proteins
January 2025
Department of Pediatrics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Catheter-associated urinary tract infections (CAUTIs) account for a large proportion of healthcare-associated infections. CAUTIs, caused by colonization of the catheter surface by uropathogens, are challenging to treat, especially when compounded by antibiotic resistance. One prophylactic strategy that could reduce pathogen colonization is bacterial interference, whereby the catheter surface is coated with non-pathogenic bacteria.
View Article and Find Full Text PDFRoot-filling materials for endodontic surgery: biological and clinical aspects.
Biomater Investig Dent
October 2024
Section of Endodontics, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway.
The placement of root filling materials aims to prevent the occurrence of post-treatment apical periodontitis following completion of endodontic treatment. Materials should possess properties that will not permit bacterial invasion and infection, namely excellent sealing ability and/or antibacterial properties. In root-end filling procedures or repair of root perforations, the root filling materials are placed in a particularly challenging clinical environment, as they interface with a relatively large area with the periradicular tissues.
View Article and Find Full Text PDFCoordination Compounds as Antivirals against Neglected Tropical Diseases.
ChemMedChem
November 2024
Laboratory of Synthesis of Bioinspired Molecules, Institute of Chemistry, Federal University of Uberlândia-UFU, João Naves de Avila Avenue, 2121, 38408-100, Uberlândia, Minas Gerais, Brazil.
Neglected tropical viral diseases are a burden to social and economic welfare being responsible for higher pathogen-related mortality rates and chronic debilitating patient conditions. Climatic changes have widened up the infectibility ratio of such diseases, with autochthonous transmission in formerly temperate-to-cold environments. The slow-paced development of potential vaccines followed by the inexistence of antiviral drugs for such diseases considerably worsens the situation.
View Article and Find Full Text PDFMiR-130c-5p targets the SHVV gene and upregulates immune cytokines (IL-6, IL-22, IL-1β) to inhibit viral replication.
Front Immunol
November 2024
Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, China.
Article Synopsis
- SHVV infection causes significant economic losses in snakehead aquaculture, and the role of microRNAs, especially miR-130c-5p, in the viral infection process is being studied.
- Research shows that SHVV infection increases miR-130c-5p levels in channel catfish ovary cells, and manipulating its expression can either inhibit or promote SHVV replication.
- miR-130c-5p not only targets and degrades viral mRNA but also enhances the expression of important immune-related genes, contributing to the host's defense against the virus.
High-Performance Acousto-Hydraulic method for generating fine aerosols for air and surface disinfection.
Ultrason Sonochem
December 2024
Biysk Technological Institute, Biysk, Russia.
Liquid atomization is utilized across various industrial applications, including nanopowder production, spray drying, fuel combustion, coating applications, emulsion preparation, and in medical devices. The use of ultrasonic energy for atomization offers advantages in terms of environmental sustainability compared to other methods. Notably, ultrasonic atomization can achieve finer dispersion with a narrow droplet size distribution at relatively low energy consumption, which is crucial for certain technological applications.
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