For several years now, it is possible to test the cochlear function immediately after birth in an easy way by means of click evoked otoacoustic emissions. Thanks to this early detection, hearing aid fitting and appropriate hearing rehabilitation can now be started at a very young age, which significantly enhances the possibility of integration of the congenitally hard of hearing in society. An international consensus is growing to endorse a universal neonatal hearing screening in western societies. Setting up screening programs necessitates good preparation, continuous quality control and regular analysis of procedures and results. The present paper evaluates the procedure as organised from January 1993 till December 1994 in the University ENT-Department of the Sint-Augustinus Hospital. Of the 907 included neonates who were considered not to be at risk for hearing loss, 81% passed the test immediately, and 93% passed after maximum 3 tests. Some changes in the initial procedure increased the prevalence of emissions from 69% to 84%. The practical problems of the screening program and especially the importance of a stringent follow-up procedure in case of failure, are discussed.
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BMC Ophthalmol
January 2025
Division of Ophthalmology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Ave, Chicago, IL, 60611, United States of America.
Background: Congenital cytomegalovirus (CMV) infections are associated with eye manifestations, especially in patients with systemic disease. However, there are no ophthalmic screening guidelines for infants with congenital CMV.
Methods: Retrospective review of pediatric patients (< 18 years old, 2010-2023) with a diagnosis of congenital CMV and at least 1 eye examination.
Obstet Gynecol
January 2025
Medical Practice Evaluation Center, the Division of Infectious Disease, and the Division of Maternal Fetal Medicine, Massachusetts General Hospital, Boston, Massachusetts; the Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada; and the Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, New York.
The purpose of this review is to serve as an update on congenital cytomegalovirus (CMV) evaluation and management for obstetrician-gynecologists and to provide a framework for counseling birthing people at risk for or diagnosed with a primary CMV infection or reactivation or reinfection during pregnancy. A DNA virus, CMV is the most common congenital viral infection and the most common cause of nongenetic childhood hearing loss in the United States. The risk of congenital CMV infection from transplacental viral transfer depends on the gestational age at the time of maternal infection and whether the infection is primary or nonprimary.
View Article and Find Full Text PDFGenet Med
January 2025
Newborn Screening Ontario, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada; Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa. Electronic address:
Purpose: Universal newborn hearing screening (UNHS) programs using audiometric techniques alone are limited in ability to detect non-congenital childhood permanent hearing loss (PHL). In 2019, Ontario launched universal newborn screening (NBS) for PHL risk factors: congenital cytomegalovirus (cCMV) and 22 common variants in GJB2 and SLC26A4. Here we describe our experience with genetic risk factor screening.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Pediatrics, AIIMS Jodhpur, Jodhpur, Rajasthan, India.
Cytomegalovirus (CMV) infection is one of the most common congenital infections. We present a case of an infant who presented with respiratory distress since birth with a normal antenatal history. The infant had bilateral pleural effusion.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Pediatrics, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
This case report presents a late preterm infant diagnosed with severe cerebellar hypoplasia and microcephaly secondary to congenital cytomegalovirus (cCMV) infection. Initially suspected to have Dandy-Walker malformation, postnatal MRI revealed significant cerebellar hypoplasia, without other typical cCMV findings. The diagnosis was confirmed by the presence of CMV in serum and urine.
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