Objective: To study the prevalence of glucose intolerance in adult urban and rural populations in the northern parts of Sudan.
Research Design And Methods: A sample of 1,284 subjects aged > or = 25 years was selected using a multistage cluster method and underwent a 75-g oral glucose tolerance test.
Results: The crude prevalence was 3.4% (men, 3.5%; women, 3.4%) for diabetes and 2.9% (men, 2.2%; women, 3.3%) for impaired glucose tolerance (IGT). The highest crude prevalence was in the northern parts of Sudan (5.5%) and the lowest in the western desert-like parts (0.9%). Diabetes and IGT rates were not different between the urban and rural populations. New cases (2.2%) were almost twice as prevalent as previously known cases (1.3%). Family history of diabetes, obesity, and advanced age were associated with higher rates of diabetes.
Conclusion: The results showed a high prevalence of diabetes in the adult population of Sudan, with a wide difference among the different areas. The high ratio of newly discovered to previously known diabetic cases may reflect poor public awareness and medical services. These findings will certainly have far-reaching implications for diabetes care delivery in this country.
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http://dx.doi.org/10.2337/diacare.19.10.1126 | DOI Listing |
J Endocrinol Invest
January 2025
Department of Medical Area, Section of Metabolic Diseases and Diabetes, University Hospital of Pisa, Via Paradisa, 2, Pisa, 56124, Italy.
Purpose: Women with gestational diabetes (GDM) have increased risk of hypertensive disorders in pregnancy (HDP). However, knowledge remains limited for women with high-risk metabolic profiles, regardless of GDM diagnosis. This study aimed to evaluate the prevalence of HDP among women at high risk for GDM, while simultaneously identifying potential predictive clinical risk factors of HDP.
View Article and Find Full Text PDFFront Mol Biosci
January 2025
Division of Maternal and Fetal Medicine, Fundación Para la Investigación Biomédica, La Paz University Hospital, Madrid, Spain.
Introduction: Gestational diabetes mellitus (GDM) is a global health concern with significant short and long-term complications for both mother and baby. Early prediction of GDM, particularly late-onset, is crucial for implementing timely interventions to mitigate adverse outcomes. In this study, we conducted a comprehensive metabolomic analysis to explore potential biomarkers for early GDM prediction.
View Article and Find Full Text PDFLett Appl Microbiol
January 2025
Panxi Crops Research and Utilization Key Laboratory of Sichuan Province, Xichang University, Liangshan, China.
Levilactobacillus brevis YT108, identified for its ability to metabolize prebiotic xylo-oligosaccharides (XOS), emerges as a candidate for probiotic use in synbiotic food formulations. This study aimed to investigate the metabolic and genomic traits associated with XOS metabolism in YT108 and to assess its probiotic attributes through whole genome sequencing and in vitro assays. Strain YT108 exhibited robust growth kinetics on XOS as the sole carbon source, with a growth profile comparable to that on glucose, achieving a pH reduction to 4.
View Article and Find Full Text PDFBMJ Open
January 2025
Department of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester LE3 9QP, UK
Introduction: Heart failure with preserved ejection fraction (HFpEF) is characterised by severe exercise intolerance, particularly in those living with obesity. Low-energy meal-replacement plans (MRPs) have shown significant weight loss and potential cardiac remodelling benefits. This pragmatic randomised trial aims to evaluate the efficacy of MRP-directed weight loss on exercise intolerance, symptoms, quality of life and cardiovascular remodelling in a multiethnic cohort with obesity and HFpEF.
View Article and Find Full Text PDFInt J Psychophysiol
January 2025
Center for Cognitive & Brain Health, Northeastern University, Boston, MA, USA; Department of Physical Therapy, Movement, & Rehabilitation Sciences, Northeastern University, Boston, MA, USA. Electronic address:
Introduction: Prolonged sitting can acutely reduce working memory (WM) in individuals with overweight and obesity (OW/OB) who show executive function deficits. Interrupting prolonged sitting with brief PA bouts may counter these effects. However, the benefits of such interventions on behavioral and neuroelectric indices of WM and whether neurocognitive responses are associated with postprandial glycemic responses in young and middle-aged adults with OW/OB remain unknown.
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