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Upstream sequence of the parahydroxyphenyl-pyruvate dioxygenase (melA) coding region leading to enhanced expression in Shewanella colwelliana. | LitMetric
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Upstream sequence of the parahydroxyphenyl-pyruvate dioxygenase (melA) coding region leading to enhanced expression in Shewanella colwelliana.

C L Eylem E J Quintero R M Weiner

Microbios

Department of Microbiology, University of Maryland, College Park 20742, USA.

Published: December 1996

Hyperexpression of the enzyme, parahydroxyphenylpyruvate dioxygenase (pHPPH; melA), in the tyrosine degradative pathway yields excess homogentisic acid which oxidatively polymerizes to pyomelanin. Depression of melA in Shewanella colwelliana strain D was found to result from a single base pair transition upstream of the promoter. This was the sole lesion detected in pHPPH hyperexpressing strains. It is suggested that a T to C transition alters the mRNA structure, exposing the ribosome binding site, thereby enhancing translational efficiency.

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