Study Design: This is a case report.
Objectives: To present a case of cervical kyphosis after resolution of myopathic head drop.
Summary Of Background Data: Myopathic head drop is a severe and persistent local myopathy that never progresses beyond the neck extensor muscles.
Methods: A case is reported of a hospitalized psychiatric patient who experienced the sudden onset of severe neck extensor weakness consistent with myopathic head drop.
Results: Although myopathic head drop resolved after 2 years, it left a disabling residual skeletal deformity of the cervical spine.
Conclusions: Myopathic head drop may be a cause of cervical kyphosis.
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http://dx.doi.org/10.1097/00007632-199609010-00020 | DOI Listing |
J Neurol
December 2024
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Background: PNPLA8 is a gene that causes an autosomal recessive mitochondrial disease characterised by microcephaly and intractable epilepsy in infants and cerebellar ataxia and limb weakness in adults. Herein, we report the clinical, muscle pathology, and brain imaging features of an adult patient with new variants of PNPLA8.
Methods: A 27-year-old Chinese woman presented with abnormal gait at age 11, remained amenorrhoeic with an infantile uterus at age 17, and presented with head and limb tremors at age 21.
Rinsho Shinkeigaku
September 2023
Department of Neurology, Kansai Medical University.
A 61-year-old woman was treated with atezolizumab plus bevacizumab for hepatocellular carcinoma with peritoneal dissemination. Blood tests revealed elevated creatine kinase (CK) that peaked at 2,657 U/l. After two cycles of atezolizumab plus bevacizumab combination therapy, she complained of progressive dysarthria and dysphagia.
View Article and Find Full Text PDFPLoS One
April 2023
Department of Otolaryngology and Head and Neck surgery, Division of Neuro-Laryngology, Voice, and Swallowing Disorders, Puerta de Hierro Majadahonda University Hospital, Universidad Autónoma de Madrid, IDIPHISA, Madrid, Spain.
Background: Despite being a new entity, there is a large amount of information on the characteristics of SARS-CoV-2 infection and the symptoms of the acute phase; however, there are still many unknowns about the clinical features and pathophysiology of post-COVID syndrome. Refractory chronic cough is one of the most prevalent symptoms and carries both a medical problem and a social stigma. Many recent studies have highlighted the role of SARS-CoV-2 neurotropism, but no studies have demonstrated vagus nerve neuropathy as a cause of persistent chronic cough or other COVID-19 long-term effects.
View Article and Find Full Text PDFFront Neurol
December 2022
Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.
Background: Propionic acidemia (PA) is an inherited autosomal recessive metabolic disorder that is classified as early-onset or late-onset, depending on the onset time of clinical symptoms. It clinically manifests as numerous lesions in the brain, pancreas, liver, and muscle. Muscle biopsies show myopathic changes, which help to distinguish late-onset propionic acidemia from other metabolic diseases involving muscles.
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