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Evaluating the association between lipidome and female reproductive diseases through comprehensive Mendelian randomization analyses.
Sci Rep
January 2025
Department of Anesthesiology, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
This study aimed to assess the causal relationship between lipidome and female reproductive diseases (FRDs) using an advanced series of Mendelian randomization (MR) methods. This study utilized genome-wide association study (GWAS) summary statistics encompassing 179 lipidomes and six prevalent FRDs, namely polycystic ovary syndrome (PCOS), endometriosis, uterine fibroid, female infertility, uterine endometrial cancer, and ovarian cancer. The two-sample MR (TSMR) approach was employed to investigate the causal relationships, with further validation using false discovery rate (FDR) and multivariable MR (MVMR) methods.
View Article and Find Full Text PDFGrating-based x-ray dark-field mammography: Assessing complementary imaging information in simple cystic lesions and typical fibroadenoma.
Med Phys
January 2025
Breast Imaging Department, Red Cross Hospital Munich, Munich, Germany.
Background: A significant proportion of false positive recalls of mammography-screened women is due to benign breast cysts and simple fibroadenomas. These lesions appear mammographically as smooth-shaped dense masses and require the recalling of women for a breast ultrasound to obtain complementary imaging information. They can be identified safely by ultrasound with no need for further assessment or treatment.
View Article and Find Full Text PDFKnowledge of the Benefits and Risks of Oral Contraceptive Use Among Women of Reproductive Age in Western Saudi Arabia: A Descriptive Cross-Sectional Study.
Cureus
December 2024
Obstetrics and Gynaecology, Umm Al-Qura University, Makkah, SAU.
Article Synopsis
- Oral contraceptives (OCs) are commonly used by women for pregnancy control and health issues, but misconceptions about their benefits and risks exist.
- A study in western Saudi Arabia surveyed women aged 15-49 using an online questionnaire to assess their awareness of OCs.
- Results showed only 13.6% of participants had excellent knowledge, with most information coming from friends/relatives and physicians, highlighting a connection between reliable sources and knowledge levels.
[Use of clinical ultrasound in primary care: Hematuria].
Semergen
December 2024
Hospital Universitario San Francisco de Asís, Madrid, España; Grupo de Trabajo Ecografía SEMERGEN, España.
Hematuria is a frequent entity in primary care. The differential diagnosis covers multiple causes: physiological, pharmacological, false hematuria and urological pathologies, being fundamental in its study to assess the possible malignant neoplastic causes. Urologic ultrasound is a non-invasive technique, using a 3.
View Article and Find Full Text PDFExternal validation of the performance of commercially available deep-learning-based lung nodule detection on low-dose CT images for lung cancer screening in Japan.
Jpn J Radiol
November 2024
Department of Diagnostic Radiology, Graduate School of Biomedical and Health Science, Hiroshima University, 1-2-3 Kasumi, Minamiku, Hiroshima, 734-8551, Japan.
Article Synopsis
- The study assessed the effectiveness of a deep-learning algorithm for detecting lung nodules in low-dose CT images from lung cancer screenings in Japan.
- The algorithm achieved a high sensitivity of 96.0% for detecting lung nodules, meaning it accurately identified most of them, but had a low positive predictive value (PPV) of 24.2%, indicating many false positives.
- Despite its strong performance in sensitivity, the algorithm's tendency to produce a high number of false positives poses a significant challenge for its use in clinical settings.
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