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Network-based meta-analysis and confirmation of genes ATP1A2, FXYD1, and ADCY3 associated with cAMP signaling in breast tumors compared to corresponding normal marginal tissues.
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Department of Photo Healing and Regeneration, Medical Laser Research Center, Yara Institute, Academic Center for Education, Culture, and Research(ACECR), Tehran, Iran.
Breast cancer (BC) is a global health concern with a growing prevalence. Since BC is a heterogeneous cancer, transcriptome analyzes were carried out on breast tumor tissues relative to their corresponding normal tissues in order to identify gene expression signatures and perform meta-analysis. Five expression profiling by array data sets from breast tumor tissues and non-tumor neighboring tissues were retrieved following a search in the GEO database (GSE70947, GSE70905, GSE10780, GSE29044, and GSE42568).
View Article and Find Full Text PDFRole of Myeloid Cell-Specific Adenylyl Cyclase Type 7 in Lipopolysaccharide- and Alcohol-Induced Immune Responses.
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Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Clinical and experimental evidence indicates that alcohol use causes various abnormalities in the immune system and compromises immune functions. However, the mechanistic understanding of ethanol's effects on the immune system remains limited. Cyclic AMP (cAMP) regulates multiple processes, including immune responses.
View Article and Find Full Text PDFGenomic Insights into the Role of cAMP in Carotenoid Biosynthesis: Enhancing β-Carotene Production in via Deletion.
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Department of Molecular Science and Technology, Advanced College of Bio-Convergence Engineering, Ajou University, Woncheon-dong, Yeongtong-gu, Suwon 16499, Republic of Korea.
The gamma-ray-induced random mutagenesis of an engineered β-carotene-producing XL1-Blue resulted in the variant Ajou 45, which exhibits significantly enhanced β-carotene production. The whole-genome sequencing of Ajou 45 identified 55 mutations, notably including a reduction in the copy number of , encoding adenylate cyclase, a key enzyme regulating intracellular cyclic AMP (cAMP) levels. While the parental XL1-Blue strain harbors two copies of , Ajou 45 retains only one, potentially leading to reduced intracellular cAMP concentrations.
View Article and Find Full Text PDFCardiometabolic Modulation by Semaglutide Contributes to Cardioprotection in Rats with Myocardial Infarction.
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Department of Cardiology Center, Hebei General Hospital, Shijiazhuang, Hebei, 050051, People's Republic of China.
Background: Acute myocardial infarction (AMI) is a significant clinical challenge. Semaglutide has therapeutic potential in cardiovascular disease management, but its specific impact and mechanisms in AMI are not fully understood.
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Chronic treatment of mixture of two iridoids proportional to prescriptional dose of Yueju improves hippocampal PACAP-related neuroinflammation and neuroplasticity signaling in the LPS-induced depression model.
J Ethnopharmacol
February 2025
Interdisciplinary Institute for Personalized Medicine in Brain Disorders, School of Chinese Medicine, Jinan University, Guangzhou, 510632, China; Zhuhai Institute of Jinan University, Zhuhai, 519070, China; Departments of Psychiatry & Clinical and Translational Institute of Psychiatric Disorders, First Affiliated Hospital of Jinan University, Guangzhou, 510632, China; Guangdong-Hong Kong-Macau Joint Laboratory of Traditional Chinese Medicine on Brain-Peripheral omeostasis and Comprehensive Health, Jinan University, Guangzhou, 510632, China. Electronic address:
Article Synopsis
- Geniposide (GP) and shanzhiside methyl ester (SM) are key compounds in the Yueju Pill, a traditional Chinese herbal medicine known for its antidepressant effects, and their combined action may enhance these effects.
- This study examined how chronic treatment with GP and SM influences antidepressant-like responses linked to the neuropeptide PACAP in a model of depression induced by neuroinflammation.
- Results showed that GP and SM treatment improved depression-related behaviors, increased PACAP expression, and altered inflammatory and neuroplasticity signaling pathways in the brains of mice, suggesting a synergistic effect and supporting the potential of these compounds as antidepressants.
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