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Background And Aims: Lipoprotein lipase (LPL) is responsible for the lipolytic processing of triglyceride-rich lipoproteins, the deficiency of which causes severe hypertriglyceridemia. Liver LPL expression is high in suckling rodents but relatively low at adulthood. However, the regulatory mechanism and functional significance of liver LPL expression are incompletely understood.
View Article and Find Full Text PDFA case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time.
BMC Endocr Disord
June 2021
Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan.
Background: Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare.
View Article and Find Full Text PDFThe Effect of Acute Continuous Hypoxia on Triglyceride Levels in Constantly Fed Healthy Men.
Front Physiol
June 2019
School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada.
Introduction: Elevated plasma triglyceride (TG) concentrations are an important contributor to deleterious metabolic alterations. Evidence in animals suggest that acute exposure to an environment with reduced oxygen inhibits plasma TG clearance and causes important rise in plasma TG, especially in the postprandial state. The objective of this study was to characterize the effects of an acute exposure to normobaric hypoxia on prandial TG levels in 2 distinct lipoprotein subtypes in healthy humans: chylomicrons which are secreted by the intestine and carry dietary lipids, and denser TG carriers (mainly VLDL), which are secreted by the liver and carry endogenous lipids.
View Article and Find Full Text PDFAn enzyme-linked immunosorbent assay for measuring GPIHBP1 levels in human plasma or serum.
J Clin Lipidol
July 2019
Department of General Internal Medicine, Kanazawa Medical University, Kanazawa, Ishikawa, Japan; Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. Electronic address:
Background: Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), a glycosylphosphatidylinositol (GPI)-anchored protein of capillary endothelial cells, transports lipoprotein lipase to the capillary lumen and is essential for the lipolytic processing of triglyceride-rich lipoproteins.
Objective: Because some GPI-anchored proteins have been detected in plasma, we tested whether GPIHBP1 is present in human blood and whether GPIHBP1 deficiency or a history of cardiovascular disease affected GPIHBP1 circulating levels.
Methods: We developed 2 monoclonal antibodies against GPIHBP1 and used the antibodies to establish a sandwich enzyme-linked immunosorbent assay (ELISA) to measure GPIHBP1 levels in human blood.
The majority of lipoprotein lipase in plasma is bound to remnant lipoproteins: A new definition of remnant lipoproteins.
Clin Chim Acta
October 2016
Department of General Medicine, Kanazawa Medical University, Ishikawa, Japan; Department of Molecular Biosciences, School of Veterinary Medicine, Department of Nutrition, University of California, Davis, CA, USA; Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan; Lipid Metabolism Laboratory, Human Nutrition Research Center on Aging, Tufts University, Tufts University School of Medicine, Boston, MA, United States. Electronic address:
Background: Lipoprotein lipase (LPL) is a multifunctional protein and a key enzyme involved in the regulation of lipoprotein metabolism. We determined the lipoproteins to which LPL is bound in the pre-heparin and post-heparin plasma.
Methods: Tetrahydrolipstatin (THL), a potent inhibitor of serine lipases, was used to block the lipolytic activity of LPL, thereby preventing changes in the plasma lipoproteins due to ex vivo lipolysis.
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