It is generally accepted that glycoconjugates secreted by salivary glands are important in the protection of the oral environment. Studies with diabetic rodents have shown that their salivary glands are adversely affected. Little effort has been made to determine whether altered synthesis and/or secretion of glycoconjugates occur in salivary glands of diabetic individuals, either human or non-human. The major salivary glands of male Swiss-Webster mice, rendered diabetic with alloxan, were examined and compared to controls. Sections of major salivary glands were examined using a battery of non-lectin staining methods for glycoconjugates. Granular duct diameters were measured in sections of the submandibular glands (SM) from controls and all experimental groups. Neutral glycoconjugate staining in SM acini of glands from diabetic animals was depressed, while staining of acidic glycoconjugates increased. Neutral glycoconjugate staining in granular ducts of SM glands of diabetic animals was depressed, as were granule content and granular duct diameters. Induced diabetes did not affect staining of neutral glycoconjugates in parotid glands but staining of acidic non-sulfated glycoconjugates appeared to increase. There were no apparent differences in neutral or acidic glycoconjugate staining of sublingual (SL) glands of diabetic or control mice.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1076/ejom.34.3.187.13039 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In silico screening and immunogenic features of putative tick cement protein PA107 from Ixodes ricinus tick.
Exp Appl Acarol
January 2025
Group for Medical Entomology, Centre of Excellence for Food- and Vector-Borne Zoonoses, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Tick salivary proteins are crucial for efficient and successful tick feeding. Most of them are still uncharacterized, especially those involved in the formation of tick cement. Tick salivary protein PA107 is a putative cement protein, which is transcribed in salivary glands during the initial phase of tick feeding.
View Article and Find Full Text PDFObjective: This study aims to evaluate the clinical efficacy of electro-pneumatic intracorporeal lithotripsy for the treatment of salivary gland stones.
Study Design: A prospective cohort study of patients diagnosed with obstructive salivary gland syndrome, where basket-assisted sialendoscopy alone failed to remove the calculi.
Setting: This study was conducted at the "Queen Maria" Military Hospital in Brașov, Romania, and a private practice, between February 2023 and May 2024.
Massive subcutaneous filariosis by in beech marten () in Italy.
Parasite Epidemiol Control
February 2025
Veterinary Medicine and Animal Production Department, Naples University, 8 Via Mezzocannone, 80138 Naples, Italy.
The beech marten () is a small-size mustelid endangered according to the IUCN Red List. Despite the plethora of parasites potentially affecting its population decline, subcutaneous filarioids are occasionally reported in martens and their competent arthropod vectors are to date unknown. Therefore, from January 2023 to August 2024, this study investigated the presence of subcutaneous filarioids and ectoparasites of road-killed beech martens ( = 7) from southwestern Italy.
View Article and Find Full Text PDFInvolvement of metformin and aging in salivary expression of ACE2 and TMPRSS2.
Biofactors
January 2025
Department of Oral Disease Research, National Center for Geriatrics and Gerontology, Obu, Japan.
SARS-CoV-2-related proteins, ACE2 and TMPRSS2, are determinants of SARS-CoV-2 infection. Although these proteins are expressed in oral-related tissues, their expression patterns and modulatory mechanisms in the salivary glands remain unknown. We herein showed that full-length ACE2, which has both a fully functional enzyme catalytic site and high-affinity SARS-CoV-2 spike S1-binding sites, was more highly expressed in salivary glands than in oral mucosal epithelial cells and the lungs.
View Article and Find Full Text PDFOral health-related quality of life in primary Sjögren's Syndrome.
Med Oral Patol Oral Cir Bucal
January 2025
465 Jose Marmol St, Zip Code 1236 Buenos Aires City, Argentina
Background: Primary Sjögren Syndrome (pSS) is an autoimmune disease that usually affects salivary glands. Research about the impact of oral health in quality of life of patients with pSS is scarce.
Objectives: to describe the characteristics of oral involvement in patients with pSS; To assess quality of life related to oral health (QOL-OH); to determine association between QOL-OH and saliva production, disease activity, and damage.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!