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Retinal vascular structure independently predicts the initial treatment response in neovascular age-related macular degeneration.
Acta Ophthalmol
February 2024
Department of Ophthalmology, Odense University Hospital, Odense, Denmark.
Purpose: Prediction of the early treatment response is important in neovascular age-related macular degeneration (nAMD). Hence, we aimed to test if non-invasive measurements of the retinal vascular structure were able to predict a successful outcome of initial intravitreal treatment.
Methods: In 58 eyes of 58 patients with treatment-naïve nAMD, advanced markers of retinal vascular structure were measured by Singapore I Vessel Assessment prior to initial intravitreal treatment with three monthly injections of aflibercept with subsequently categorization of patients as full treatment responders (FTR) or non/partial treatment responders (N/PR), with the former defined as loosing fewer than five Early Treatment Diabetic Retinopathy Study letters and having no residual intra- or subretinal fluid or macular haemorrhage.
Background This study examined the association between ideal cardiovascular health ( CVH ) and the retinal microvasculature in midadulthood. Methods and Results The Cardiovascular Risk in Young Finns Study included children from 5 Finnish University cities, who were chosen randomly from the national population register. Participants ranged from 12 to 18 years in childhood (1986) and from 37 to 43 years in midadulthood (2011).
View Article and Find Full Text PDFRetinal vascular geometry and its association to microvascular complications in patients with type 1 diabetes: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987).
Graefes Arch Clin Exp Ophthalmol
February 2017
Department of Ophthalmology, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense C, Denmark.
Purpose: To examine associations between retinal vascular geometry (tortuosity, branching coefficient [BC] and length-diameter ratio [LDR]) and diabetic proliferative retinopathy (PDR), nephropathy, and peripheral neuropathy in patients with type 1 diabetes mellitus (T1DM).
Methods: A cohort of patients with T1DM participated in a clinical examination in 2011. Blood and urine analyses were done and retinal images taken.
Vitamin D deficiency is not associated with changes in retinal geometric parameters in young people with type 1 diabetes.
J Diabetes Res
January 2014
Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia.
Changes in retinal geometric parameters predict risk and progression of diabetic retinopathy (DR). We have shown that vitamin D deficiency (VDD) is associated with DR. We hypothesized that VDD mediates changes in retinal geometric parameters.
View Article and Find Full Text PDFDoes retinal vascular geometry vary with cardiac cycle?
Invest Ophthalmol Vis Sci
August 2012
School of Electrical and Computer Engineering, Royal Melbourne Institute of Technology (RMIT University), Melbourne, Australia.
Purpose: Changes in retinal vascular parameters have been shown to be associated with systemic vascular diseases. In this study, we assessed the physiologic variations in retinal vascular measurements during the cardiac cycle.
Methods: Fundus images were taken using electrocardiogram-synchronized retinal camera at nine distinct cardiac points from 15 healthy volunteers (135 images).
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