The studies were conducted on Balb/c mice exposed to restraint stress twice for 12 h at 24 h intervals. Some of the experimental mice were immunized i.p. with sheep red blood cells (SRBC). The antigen was injected before the first exposure of the mice to restraint stress, or immediately after the second loading was ended. Sodium diethyldithiocarbamate (DTC) at a dose of 20 mg/kg or calf thymus extract (TFX) at a dose of 10 mg/kg were injected i.p. four times at 24 h intervals, before or after the exposure to restraint stress. In our experiment restraint stress drastically reduced the number of thymocytes and splenocytes as well as the weight ratio of the thymus and spleen and the changes sustained for 10 days of the observation. Besides, humoral response of the restrained mice to SRBC was deteriorated, as the number of plaque forming cells (PFC) and anti-SRBC antibody titers (total and 2-mercaptoethanol resistant) decreased. The suppressive action of the stress on humoral response was weaker when the antigen injection preceded the first exposure of mice to restraint stress as compared with that observed when antigen stimulation took place immediately after the exposure of mice to stress. It has been found that DTC and TFX administered to mice either before or after the exposure to restraint stress effectively inhibit stress-induced immunosupression. The protective or immunomodulating action of the two drugs is expressed in accelerated and enhanced recovery of the spleen and thymus and in total or partial restoration of the humoral response to thymus-dependent antigen. TFX, administered after the exposure of mice to restraint stress, proves to have a stronger protective and reconstructive impact on thymus, while DTC has a stronger restoring effect on the humoral response dependent on effector T lymphocytes. DTC administered immediately after the exposure of mice to restraint stress results in total restoration of humoral response to SRBC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/08923979609052744 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The objective of this Scientific Opinion is to assess the hazards and welfare consequences associated with the slaughter of horses for human consumption. The entire slaughter procedure, from arrival at the slaughterhouse until death, is divided into three phases: Phase 1 - pre-stunning, Phase 2 - stunning and Phase 3 - bleeding. Phase 1 includes the following processes (in chronological order): (a) arrival, (b) unloading of the animals from the vehicle, (c) lairage, (d) handling and moving to the stunning area and (e) restraint before application of the stunning method.
View Article and Find Full Text PDFHorses of different ages may have to be killed on-farm for purposes other than slaughter (where slaughter is defined as killing for human consumption) either individually (i.e. on-farm killing of unproductive, injured or terminally ill animals) or on a large-scale (i.
View Article and Find Full Text PDFTrajectories and predictors of maternal eating behaviors across the first year postpartum: The role of women's childhood trauma in emotional, external and restraint eating.
Eat Behav
January 2025
Department of Health Behavior and Health Education, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.
The first year postpartum is a sensitive time for maternal eating behaviors including emotional, external and restrained eating, which have all been associated with negative health outcomes. Furthermore, among women with a history of trauma, the stress of the postpartum period and early parenting may replicate feelings of helplessness and overwhelm experienced during childhood trauma, which may further contribute to these eating behaviors. Although evidence has shown how mothers eat during this time has long-term implications for infants' eating and health, limited research has characterized eating trajectories and associations with women's history of childhood trauma exposure during this critical period.
View Article and Find Full Text PDFYeokwisan: Standardised Herbal Formula Enhancing Gastric Mucosal Protection Against Gastric Ulcers in Mice, a Preclinical Study.
Pharmaceuticals (Basel)
January 2025
KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea.
: Yeokwisan (YWS) is a standardised herbal formula for relieving functional dyspepsia symptoms. : We explored the therapeutic value of YWS and its potential effects on gastritis. Its inhibitory effect on gastric mucosal damage and anti-inflammatory activity in animal models of alcohol- and restraint stress-induced gastritis were also examined.
View Article and Find Full Text PDFExpansion Characteristics and Shear Behavior of Reinforced Concrete Beams Under Non-Uniform Expansion Induced by Alkali-Silica Reaction.
Materials (Basel)
January 2025
Engineering Research Centre of Diagnosis Technology of Hydro-Construction, Chongqing Jiaotong University, Chongqing 400074, China.
Alkali-silica reaction (ASR) is an important factor that seriously affects the durability of reinforced concrete (RC) structures. The current research on alkali-aggregate mainly focuses on the deterioration mechanism of materials and the mechanical properties of standard specimens. However, there is a gap in the field of research on the effect of alkali-aggregate damage on the level of RC structures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!